Now showing items 1-5 of 10247

    • Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031 

      Sarr, Awa; Bré, Jennifer; Um, In Hwa; Chan, Tsz Huen; Mullen, Peter; Harrison, David J.; Reynolds, Paul A. (2019-05-21) - Journal article
      Gemcitabine is a fluoropyrimidine analogue that is used as a mainstay of chemotherapy treatment for pancreatic and ovarian cancers, amongst others. Despite its widespread use, gemcitabine achieves responses in less than ...
    • Non-Poisson variations in photomultipliers and implications for luminescence dating 

      Carter, John; Cresswell, Alan; Kinnaird, Timothy Charles; Carmichael, Lorna; Murphy, Simon; Sanderson, David (2018-12-15) - Journal article
      Previous studies have suggested that excess variations from single-photon counting systems used in luminescence dating may result in underestimation of errors and profoundly influence age models. In this study ten different ...
    • Reflecting the now : project management and contemporary collecting in a multi-disciplinary museum 

      Alberti, Samuel J. M. M.; Allen, Stephen; Dectot, Xavier; Gill, Ruth (2018-01-10) - Journal article
      Nearly two million visitors a year will pass through the new permanent galleries of the National Museum of Scotland in Edinburgh. This article reflects on the planning and collecting that presaged their redevelopment in ...
    • Two-dimensional Ising model with Einstein site phonons 

      Pili, L.; Grigera, S. A. (2019-04-23) - Journal article
      We consider a simple Ising magnetic model in two dimensions with Einstein site phonons and study it using Monte Carlo simulations that take into account both degrees of freedom simultaneously. In nonfrustrated systems, ...
    • The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning 

      Swanston, Amy; Zabrady, Katerina; Ferreira, Helder C. (2019-05-20) - Journal article
      Topoisomerase II (Top2) is an essential enzyme that decatenates DNA via a transient Top2-DNA covalent intermediate. This intermediate can be stabilised by a class of drugs termed Top2 poisons, resulting in massive DNA ...