Chemistry: Recent submissions
Now showing items 301-305 of 897
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Metal organic frameworks : from anticancer multifunctional drug delivery systems to novel vaccine adjuvants
(University of St Andrews, 2016) - ThesisThe research presented in this thesis aims to assess the capacity of metal organic frameworks for potential applications as drug delivery systems and novel vaccine adjuvants. The opening chapter (Chapter 1) provides a ... -
Structural and mechanistic studies on the biosynthesis of the 3'-deoxy nucleoside of the pacidamycins
(University of St Andrews, 2018-03) - ThesisNucleic acids are ubiquitous in nature and modified nucleosides are present in a wide range of anti-viral, anti-cancer drugs and antibiotics. Although a variety of naturally occurring nucleoside analogues exist, few include ... -
α functionalization of carbonyl compounds via Brønsted and Lewis base organocatalysis
(University of St Andrews, 2018-05) - ThesisThis thesis describes the development of new methodologies promoted by bifunctional Brønsted basic H-bonding catalysis and Lewis basic organocatalysts. Chapter 2 describes the synthesis of novel chiral guanidines and their ... -
Target elucidation of novel trypanosomatid inhibitors
(University of St Andrews, 2018-03) - ThesisIn 2010 the Florence group completed the total synthesis of the natural product chamuvarinin which, in collaboration with the Smith group, was found to be a potent inhibitor of the pathogenic parasite T. brucei. Several ... -
A manifold destiny : advancing the frontiers of the ADOR process
(University of St Andrews, 2017) - ThesisThis thesis deals with the various attempts to expand the ADOR (Assembly, Disassembly, Organisation and Reassembly) process. This includes the use of the ADOR process to incorporate new elements into a zeolite framework, ...