Medicine Theses: Recent submissions
Now showing items 16-20 of 155
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Investigating the DNA methylation landscape of Staphylococcus aureus
(University of St Andrews, 2022-06-17) - ThesisStaphylococcus aureus is a leading causative agent of healthcare-associated infections. One aspect of the organism that remains unknown is the methylome, specifically that of the whole genome. In prokaryotes, methylation ... -
Statistical underpinning of mutational signature analyses of cancer sequencing data
(2024-06-11) - ThesisCancer is a disease driven and characterised by mutations in the DNA. Thanks to massively parallel sequencing technologies, it is now possible to obtain the sequence of a cancer genome. The advent of modern sequencing ... -
Developing a hybrid agent-based mathematical model to study bladder infections
(2024-06-14) - ThesisUrinary Tract Infections (UTIs) are amongst the most common infections worldwide, affecting well over 150 million people each year. UTIs now account for 40% of all hospital-acquired infections and they are becoming harder ... -
Towards fully automated analysis of sputum smear microscopy images
(2024-12-03) - ThesisSputum smear microscopy is used for diagnosis and treatment monitoring of pulmonary tuberculosis (TB). Automation of image analysis can make this technique less laborious and more consistent. This research employs artificial ... -
Circulatory zinc dyshomeostasis as a novel contributor of thrombosis in obesity and Type II diabetes mellitus
(2024-06-14) - ThesisIndividuals with obesity and Type II diabetes mellitus are particularly susceptible to pathological thrombosis. Notably, the formation of highly compact clots which are resistant to breakdown is likely to contribute to ...