Chemistry (School of): Recent submissions
Now showing items 206-210 of 897
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Studies on selectively fluorinated cycloalkanes
(University of St Andrews, 2020-07-29) - ThesisThe thesis focuses on the synthesis of novel fluorinated cycloalkanes and their polar properties. Chapter 2 describes the synthesis of all cis-1,2,3,4-tetrafluorocyclopentane and its deuterated isotopomer. They were ... -
Genome sequencing, analysis, heterologous expression and genetic modification of antibiotic encoding biosynthetic gene clusters
(University of St Andrews, 2020-06) - ThesisMicrobial natural products represent an unparalleled starting point for drug discovery. This thesis therefore focuses on microbial natural products, and the biosynthetic gene clusters (BGCs) that encode them. A series ... -
Developing genetic and chemical tools for the GenoChemetic generation of natural product analogues
(University of St Andrews, 2020-06) - ThesisNatural products provide one of the corner stones of both modern and historical medicine, contributing towards over 65 % of new FDA approved drugs that entered clinical trials between 1981 and 2014. It is partly down to ... -
Catalytic enantioselective acyl transfer for the synthesis of atropisomers
(University of St Andrews, 2020-06-24) - ThesisThis thesis details the development of enantioselective, isothiourea-catalysed, acyl-transfer methodology for the synthesis of atropisomers. Chapter 1 aims to introduce organocatalysis in the context of the current ... -
Insights into the structure and reactivity of the biopolymer lignin using diffusion ordered spectroscopy and synthetic model studies
(University of St Andrews, 2020-06-24) - Thesis