Biomedical Sciences Research Complex (BSRC) Theses: Recent submissions
Now showing items 6-10 of 15
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Structural studies on human dihydroxyacetone kinase (DAK) and the carbohydrate-binding domain of Streptococcus pneumoniae NanA
(University of St Andrews, 2013) - ThesisA number of dihydroxyacetone kinases (DAK) have been described that can utilize either ATP (in animals, plants and some bacteria) or phosphoenolpyruvate (PEP) (in most bacteria) as the energy source to convert dihydroxyacetone ... -
Structural and functional characterisation of Mcb1 and the MCMᴹᶜᵇ¹ complex in Schizosaccharomyces pombe
(University of St Andrews, 2014-06) - ThesisThe MCM helicase plays an important role in eukaryotic DNA replication, unwinding double stranded DNA ahead of the replication fork. MCM is a hetero-hexamer consisting of the six related proteins, Mcm2-Mcm7. The distantly ... -
Structural studies of CRISPR-associated proteins
(University of St Andrews, 2013-11-29) - ThesisClustered regularly interspaced short palindromic repeats (CRISPRs) act to prevent viral infection and horizontal gene transfer in prokaryotes. The genomic CRISPR array contains short sequences (“spacers”) that are derived ... -
Distance measurements using pulsed EPR : noncovalently bound nitroxide and trityl spin labels
(University of St Andrews, 2013-06-26) - ThesisThe function of biomacromolecules is controlled by their structure and conformational flexibility. Investigating the structure of biologically important macromolecules can, therefore, yield information that could explain ... -
Attenuation of bunyavirus replication by modification of genomic untranslated regions
(University of St Andrews, 2012-11-30) - ThesisBunyamwera orthobunyavirus (BUNV) is the prototype for the family Bunyaviridae. BUNV has a tripartite RNA genome of negative polarity composed of the large(L),medium (M)and small(S)segments. Each segment contains an open ...