Biomedical Sciences Research Complex (BSRC): Recent submissions
Now showing items 11-15 of 43
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A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner
(2015-12-22) - Journal articleThe sliding clamp PCNA plays a vital role in a number of DNA repair pathways in eukaryotes and archaea by acting as a stable platform onto which other essential protein factors assemble. Many of these proteins interact ... -
Lipidomic analysis of fats and oils – a lot more than just omega-3
(2015-01) - Journal articleEdible oils and fats are among the most abundant cooking ingredients in the world, and are an important part of a healthy balanced diet, especially if they are high in omega-6 and omega-3 polyunsaturated fatty acids. Rather ... -
Taking a molecular motor for a spin : helicase mechanism studied by spin labelling and PELDOR
(2015-12-10) - Journal articleThe complex molecular motions central to the functions of helicases have long attracted attention. Protein crystallography has provided transformative insights into these dynamic conformational changes, however important ... -
Identification of a candidate Rad1 subunit for the kinetoplastid 9-1-1 (Rad9-Hus1-Rad1) complex
(2014-12-19) - Journal articleThe trimeric 9-1-1 (Rad9-Hus1-Rad1) complex plays an important role in the eukaryotic DNA damage response by recruiting DNA repair factors and checkpoint mediators to damaged sites. Extensively characterised in mammals and ... -
Molecular studies of the Tacaribe virus nucleoprotein (NP) : identification and characterisation of virus-host interactions as novel anti-arenavirus drug targets
(University of St Andrews, 2014) - ThesisArenaviruses cause an estimated 300,000 – 500,000 infections annually. Currently there is no arenavirus-specific antiviral drug available to treat these infections. This study sought to use the non-pathogenic New World ...