St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  • Register / Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

A fibrinolytic acid proteinase in human plasma

Thumbnail
View/Open
NooshabehPejhanPhDThesis.pdf (37.42Mb)
Date
1984
Author
Pejhan, Nooshabeh
Supervisor
Kemp, Graham D.
Metadata
Show full item record
Abstract
An attempt has been made to purify an acid proteinase from human plasma, which is capable of dissolving fibrin clot in 1% (w/v) monochloroacetic acid. On SDS gel electrophoresis the enzyme isolated from plasma contains two protein bands with molecular weights of approximately 90,000 and 54,000. Different substrates were used to evaluate the proteolytic activity of the plasma enzyme, including fibrin clot, azo-casein, acid denatured haemoglobin (Hb), haemoglobin polyacrylamide gel (insoluble Hb), haemoglobin electrophoresis (soluble Hb) and the synthetic substrate N-acetyl-L-phenylalanyl-L-diiodotyrosine. The plasma enzyme seems to belong to the group of aspartyl proteinases as its activity against the above substrates was maximal at low pH, and was inhibited by pepstatin which is a powerful inhibitor of aspartyl proteinases.
Type
Thesis, PhD Doctor of Philosophy
Collections
  • Biology Theses
URI
http://hdl.handle.net/10023/14960

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter