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dc.contributor.advisorThomson, Colin
dc.contributor.authorEdge, Colin Michael
dc.coverage.spatial254 p.en_US
dc.date.accessioned2018-06-21T10:31:16Z
dc.date.available2018-06-21T10:31:16Z
dc.date.issued1989
dc.identifier.urihttp://hdl.handle.net/10023/14388
dc.description.abstractThe glyoxalase enzyme system catalyses the conversion of methylglyoxal to D-lactic acid. The first of the two component enzymes, glyoxalase I, is responsible for the transfer of two protons in an iscmerisation reaction. This enzyme has been ascribed a role in tumorigenesis in the past and some of its inhibitors are known to be carcinostatic. This thesis describes quantum chemical calculations on the enzyme mechanism and on some enzyme inhibitors. The calculations on the mechanism of the enzyme take the form of studies of model reaction schemes, with minimal and split-valence basis sets. The calculation of the energies of various intermediates has led to the evaluation of different pathways as models of the enzyme mechanism. The comparison of different substituted compounds has led to further conclusions on the part played by the sulphur atom in the enzyme-catalysed reaction. Two main groups of inhibitor molecules are discussed; these are flavone and coumarin derivatives. The molecular electrostatic potential of these molecules has been calculated on various surfaces, using a minimal basis set, to attempt to correlate this property with the compounds' inhibitory power. A FORTRAN program is presented which depicts calculated properties on the surfaces. This program allowed the identification of various regions which seemed to be indicative of the inhibitory strength of the compounds.en_US
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.subject.lccQP603.E3
dc.subject.lcshDiphenol oxidaseen
dc.titleTheoretical studies of enzyme inhibitionen_US
dc.typeThesisen_US
dc.contributor.sponsorNational Foundation for Cancer Research (NFCR)en_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US


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