St Andrews Research Repository: Recent submissions
Now showing items 26-30 of 28888
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Investigating resistance mechanisms to CB-839 in renal cell carcinoma using a whole-genome CRISPR/Cas9 approach
(2021-11-30) - ThesisRenal cell carcinoma (RCC) represents around 3% of all malignancies worldwide, with its most common type, clear cell RCC (ccRCC), making up around 70-80% of all RCC. RCC is characterised by significant tumour heterogeneity ... -
Bedaquiline: what might the future hold?
(2024-07-27) - Journal articleTuberculosis drug development has stagnated for decades, so the recent availability of bedaquiline is welcome. Bedaquiline-containing regimens, now the first-line therapy recommended by WHO, have transformed the treatment ... -
Developing a novel molecular bacterial load assay to improve clinical management of Mycobacterium abscessus infections
(2022-06-17) - ThesisMycobacterium abscessus (M. abscessus) is one of the most common rapid growing non- tuberculous mycobacteria (NTM) causing pulmonary disease (PD). Treatment involves long and toxic multi-drug regimens with uncertain benefit. ... -
Determination of the dynamic Young’s modulus of quantum materials in piezoactuator-driven uniaxial pressure cells using a low-frequency AC method
(2024-07) - Journal articleWe report on a new technique for measuring the dynamic Young’s modulus, E, of quantum materials at low temperatures as a function of static tuning strain, ϵ, in piezoactuator-driven pressure cells. In addition to a static ... -
Identifying coronal sources of L1 solar wind disturbances using the Fisk heliospheric magnetic field and potential field extrapolations during three solar minima
(2024-05-01) - Journal articleThe solar minima between solar cycles 22-23, 23-24, and 24-25 are the best observed minima on record. In situ solar wind and interplanetary magnetic field measurements by the Wind and ACE spacecraft at L1 with 1 hr cadence ...