Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.advisorBrown, Verity Joy
dc.contributor.authorDaggett, J. M. (Jenny Michelle)
dc.coverage.spatialx, 129 p.en_US
dc.date.accessioned2016-10-04T11:16:37Z
dc.date.available2016-10-04T11:16:37Z
dc.date.issued2016-11-30
dc.identifieruk.bl.ethos.694560
dc.identifier.urihttp://hdl.handle.net/10023/9603
dc.description.abstractCognitive deficits are the single strongest predictor of the functional outcome in patients with schizophrenia. Current treatments are largely ineffective in improving cognitive impairments and promising pre-clinical research has mostly failed to translate clinically. Despite the advances provided by rodent models, the neurobiological basis of cognitive deficits in schizophrenia is poorly understood. Therefore, this thesis proposes a zebrafish model for studying cognitive impairments of schizophrenia. Although more evolutionarily distant to humans compared to the rat, the zebrafish has emerged as a popular vertebrate model of human disorders due to its genetic tractability, complex nervous system and elaborate behavioural repertoire. We investigated the effects of genetic alterations and neurodevelopmental disruption on behaviour and learning in zebrafish. Using both disc1 mutant lines and sub-chronic phencyclidine (PCP) on larvae from 6-10 dpf, we were able to assess behavioural changes as a function of developmental age. In particular, this thesis aimed to develop appropriate behavioural assays to assess zebrafish learning and executive function relevant to disorders seen in human patients with schizophrenia. It was possible to demonstrate robust learning across several domains, namely, reversal, classical avoidance and non-associative learning, alongside locomotor and anxiety-related behaviours. There were varied deficits associated with each of the two – genetic (disc1 gene mutation) and environmental (sub-chronic PCP) – manipulations, consistent with observations in rat research. Together, the research in this thesis demonstrates that a zebrafish model exhibits behaviour resembling that of mammalian models of schizophrenia and provides a foundation for the utility of zebrafish in examining cognitive impairments associated with schizophrenia.en_US
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectZebrafishen_US
dc.subjectSchizophreniaen_US
dc.subjectCognitive flexibilityen_US
dc.subjectPhencyclidineen_US
dc.subjectHabituationen_US
dc.subjectSet shiftingen_US
dc.subjectMotivationen_US
dc.subjectNMDA receptorsen_US
dc.subject.lccRC514.D2
dc.subject.lcshSchizophrenia--Animal modelsen_US
dc.subject.lcshZebra danios as laboratory animalsen_US
dc.titleEvaluation and characterisation of two zebrafish models of schizophreniaen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US


The following license files are associated with this item:

    This item appears in the following Collection(s)

    Show simple item record

    Attribution-NonCommercial-NoDerivatives 4.0 International
    Except where otherwise noted within the work, this item's license for re-use is described as Attribution-NonCommercial-NoDerivatives 4.0 International