Biology (School of): Recent submissions
Now showing items 21-25 of 1083
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Killing the messenger : discovery of enzymes degrading cyclic oligoadenylate defence activators synthesised by type III CRISPR immune systems
(University of St Andrews, 2021-06-30) - ThesisCRISPR-Cas systems provide prokaryotes with adaptative immunity from invading Mobile Genetic Elements (MGEs). Type III CRISPR-Cas systems consist of a multiprotein effector complex and CRISPR ancillary proteins; both ... -
Investigating the gating mechanism of the large conductance mechanosensitive channel by SDSL and EPR spectroscopy
(University of St Andrews, 2020-12-01) - ThesisMechanosensation is the ability of cells to sense and respond to mechanical stimuli deriving from their environment. Despite being a fundamental cellular response though, the molecular basis of mechanotransduction is still ... -
Novel signalling pathways in type III CRISPR defence systems
(2024-06-13) - ThesisCRISPR-Cas systems offer prokaryotes an adaptive defence mechanism, allowing them to respond to the invading nucleic acids. Type III CRISPR systems feature the capacity of synthesising cyclic oligoadenylate (cOA) species, ... -
The role of ecology in sexual selection in the Heteroptera
(2024-06-12) - ThesisIn this thesis I explore our current view of sexual selection, with a focus on the insect sub-order Heteroptera and the role of ecology. I first review sexual selection in the Heteroptera across two chapters, presenting ... -
Phenotypic screening and functional characterisation of anti-protozoan unnatural products
(2024-06-12) - ThesisTrypanosoma brucei is a vector borne protozoan parasite of the class kinetoplastida and is the causative agent of human African trypanosomiasis (HAT), a neglected tropical disease of sub-Saharan Africa that is fatal if ...