Now showing items 1-20 of 1300

  • 2A - the "go-to" technology for transgene co-expression 

    Minskaia, Ekaterina; Luke, Garry Alec (2015-08-26) - Journal item
    In order to co-express multiple genes for biotechnological and biomedical applications, several approaches have been used with varying degrees of success. Currently, internal ribosome entry site (IRES) elements and ...
  • 2A peptides provide distinct solutions to driving stop-carry on translational recoding 

    Sharma, P; Yan, F; Doronina, V; Escuin-Ordinas, Helena; Ryan, Martin Denis; Brown, Jeremy (2012-04) - Journal article
    Expression of viral proteins frequently includes non-canonical decoding events (‘recoding’) during translation. ‘2A’ oligopeptides drive one such event, termed ‘stop-carry on’ recoding. Nascent 2A peptides interact with ...
  • 2A-induced ribosome stalling 

    Odon, Valèrie M. N. (University of St Andrews, 2014-06-25) - Thesis
    Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome ...
  • "2A-like" signal sequences mediating translational recoding : a novel form of dual protein targeting 

    Roulston, Claire; Luke, Garry Alec; de Felipe, Pablo; Ruan, Lin; Cope, Jonathan; Nicholson, John; Sukhodub, Andriy; Tilsner, Jens; Ryan, Martin Denis (2016-06-02) - Journal article
    We report the initial characterisation of an N-terminal oligopeptide ‘2A-like’ sequence that is able to function both as a signal sequence and as a translational recoding element. Due to this translational recoding activity, ...
  • 3D camouflage : exploiting photons to conceal form 

    Penacchio, Olivier; Lovell, Paul George; Cuthill, Innes; Ruxton, Graeme Douglas; Harris, Julie (2015-10) - Journal article
    Many animals have a gradation of body color, termed countershading, where the areas that are typically exposed to more light are darker. One hypothesis is that this patterning enhances visual camouflage by making the retinal ...
  • A 3D stereo camera system for precisely positioning animals in space and time 

    Macfarlane, Nicholas; Howland, Jonathan; Jensen, Frants; Tyack, Peter Lloyd (2015-04) - Journal article
    Here, we describe a portable stereo camera system that integrates a GPS receiver, an attitude sensor and 3D stereo photogrammetry to rapidly estimate the position of multiple animals in space and time. We demonstrate the ...
  • 4273π : bioinformatics education on low cost ARM hardware 

    Barker, Daniel; Ferrier, David Ellard Keith; Holland, Peter W.H.; Mitchell, John B. O.; Plaisier, Heleen; Ritchie, Michael Gordon; Smart, Steven D. (2013-08-12) - Journal article
    Background: Teaching bioinformatics at universities is complicated by typical computer classroom settings. As well as running software locally and online, students should gain experience of systems administration. For a ...
  • Absolute abundance estimates from shallow water baited underwater camera surveys; a stochastic modelling approach tested against field data 

    Dunlop, K.M.; Ruxton, G.D.; Scott, E.M.; Bailey, D.M. (2015-11) - Journal article
    Baited underwater cameras are becoming a popular tool to monitor fish and invertebrate populations within protected and inshore environments where trawl surveys are unsuitable. Modelling the arrival times of deep-sea ...
  • Abundance and distribution of delphinids in the Red Sea (Egypt) 

    Costa, Marina (University of St Andrews, 2015-06-24) - Thesis
    Knowledge about cetaceans in the Red Sea is limited with only a handful of sporadic or spatially-limited studies carried out to date. Funded by the Italian Cooperation through a Debt-for-Nature Swap programme and carried ...
  • Abundance and distribution of sperm whales in the Canary Islands : can sperm whales in the Archipelago sustain the current level of ship-strike mortalities? 

    Fais, Andrea; Lewis, Tim P.; Zitterbart, Daniel P.; Álvarez, Omar; Tejedor, Ana; Aguilar de Soto, Natacha (2016-03-21) - Journal article
    Sperm whales are present in the Canary Islands year-round, suggesting that the archipelago is an important area for this species in the North Atlantic. However, the area experiences one of the highest reported rates of ...
  • Abundance and survival of Pacific humpback whales in a proposed critical habitat area 

    Ashe, Erin; Wray, Janie; Picard, Christopher R.; Williams, Robert (2013-09-11) - Journal article
    Humpback whales (Megaptera novaeangliae) were hunted commercially in Canada's Pacific region until 1966. Depleted to an estimated 1,400 individuals throughout the North Pacific, humpback whales are listed as Threatened ...
  • Acoustic and ecological investigations into predator-prey interactions between Antarctic krill (Euphausia superba) and seal and bird predators 

    Cox, Martin James (University of St Andrews, 2008-11-27) - Thesis
    1. Antarctic krill (Euphausia superba) form aggregations known as swarms that vary greatly in size and density. Six acoustic surveys were conducted as part of multidisciplinary studies at two study sites, the western and ...
  • Acoustic behaviour of Risso's dolphins, Grampus griseus, in the Canary Islands, Spain 

    Neves, Silvana (University of St Andrews, 2013) - Thesis
    The Risso's dolphin (Grampus griseus) is a poorly studied species, particularly with respect to its acoustic behaviour. The little we know about Risso's dolphin acoustics shows that they are an interesting case study given ...
  • Acoustic communication in insect disease vectors 

    Vigoder, Felipe de Mello; Ritchie, Michael Gordon; Gibson, Gabriella; Peixoto, Alexandre Afranio (2013-12) - Journal article
    Acoustic signalling has been extensively studied in insect species, which has led to a better understanding of sexual communication, sexual selection and modes of speciation. The significance of acoustic signals for a ...
  • Acoustic investigations on bearded goby and jellyfish in the northern Benguela ecosystem 

    Uumati, Martha (University of St Andrews, 2013) - Thesis
    Historically the nutrient rich Benguela ecosystem supported large stocks of commercially important fish which sustained the Namibian fishing sector. Recently, non-exploited species i.e. bearded goby (Sufflogobius bibarbatus) ...
  • Acoustic mechanisms of a species-based discrimination of the chick-a-dee call in sympatric black-capped (Poecile atricapillus) and mountain chickadees (P. gambeli) 

    Guillette, Lauren; Farrell, Tara; Hoeschele, Marisa; Sturdy, Christopher (2010) - Journal article
    Previous perceptual research with black-capped and mountain chickadees has demonstrated that these species treat each other’s namesake chick-a-dee calls as belonging to separate, open-ended categories. Further, the terminal ...
  • Acoustic playback experiments to study behavioral responses of free-ranging marine animals to anthropogenic sound 

    Tyack, Peter Lloyd (2009-12-03) - Journal article
    Growing concern about the effects of anthropogenic sound on marine life has highlighted the need for empirical methods to study behavioral responses of marine animals to specific acoustic exposures. Some effects have been ...
  • Acoustic sequences in non-human animals : a tutorial review and prospectus 

    Kershenbaum, Arik; Blumstein, Dan; Roch, Marie; Akçay, Çaglar; Backus, Gregory; Bee, Mark A.; Bohn, Kirsten; Cao, Yan; Carter, Gerald; Cäsar, Cristiane; Coen, Michael; De Ruiter, Stacy Lynn; Doyle, Laurance; Edelman, Shimon; Ferrer-i-Cancho, Ramon; Freeberg, Todd M.; Garland, Ellen Clare; Gustison, Morgan; Harley, Heidi E.; Huetz, Chloé; Hughes, Melissa; Bruno, Julia Hyland; Ilany, Amiyaal; Jin, Dezhe Z.; Johnson, Michael; Ju, Chenghui; Karnowski, Jeremy; Lohr, Bernard; Manser, Marta; McCowan, Brenda; Mercado III, Eduardo; Narins, Peter M.; Piel, Alex; Rice, Megan; Salmi, Roberta; Sasahara, Kazutoshi; Sayigh, Laela; Shiu, Yu; Taylor, Charles; Vallejo, Edgar E.; Waller, Sara; Zamora-Gutierrez, Veronica (2016-02) - Journal article
    Animal acoustic communication often takes the form of complex sequences, made up of multiple distinct acoustic units. Apart from the well-known example of birdsong, other animals such as insects, amphibians,and mammals ...
  • Actin turnover is required for myosin-dependent mitochondrial movements in Arabidopsis root hairs 

    Zheng, Maozhong; Beck, Martina; Muller, Jens; Wang, Xiaohua; Wang, Qinli; Baluska, Frantisek; Logan, David; Samaj, Jozef; Lin, Jinxing (2009-06) - Journal article
    Background: Previous studies have shown that plant mitochondrial movements are myosin-based along actin filaments, which undergo continuous turnover by the exchange of actin subunits from existing filaments. Although earlier ...
  • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

    Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
    This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...