Now showing items 21-25 of 25
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer
(2015-01) - Journal article,
Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations ...
Genomic evolution of breast cancer metastasis and relapse
(2017-08-14) - Journal article,
Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
(2018-04-16) - Journal article,
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer ...
Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal
(2018-04-19) - Journal article,
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
Multi-part balanced incomplete-block designs
(2019-01-23) - Journal article,
We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some ...