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A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

Vollan, Hans Kristian Moen; Rueda, Oscar M.; Chin, Suet-Feung; Curtis, Christina; Turashuili, Gulisa; Shah, Sohrab; Lingjaerde, Ole Christian; Yuan, Yinyin; Ng, Charlotte K.; Dunning, Mark J.; Dicks, Ed; Provenzano, Elena; Sammut, Stephen; McKinney, Steven; Ellis, Ian O.; Pinder, Sarah; Purushotham, Arnie; Murphy, Leigh C.; Kristensen, Vessela N.; Brenton, James D.; Pharoah, Paul D. P.; Borresen-Dale, Anne-Lise; Aparicio, Samuel; Caldas, Carlos; Lynch, Andy (2015-01) - Journal article,

Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations ...

Genomic evolution of breast cancer metastasis and relapse

Yates, Lucy R.; Knappskog, Stian; Wedge, David; Farmery, James H. R.; Gonzalez, Santiago; Martincorena, Inigo; Alexandrov, Ludmil B.; Van Loo, Peter; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazinska, Patrycja; Bhosle, Shriram G; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J. (2017-08-14) - Journal article,

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Wedge, David C.; Gundem, Gunes; Mitchell, Thomas; Woodstock, Dan J.; Martincorena, Inigo; Ghori, Mohammed; Zamora, Jorge; Butler, Adam; Whitaker, Hayley; Kote-Jarai, Zsofia; Alexandrov, Lumil B.; Van Loo, Peter; Massie, Charlie E.; Dentro, Stefan; Warren, Anne Y.; Verrill, Clare; Berney, Dan M.; Dennis, Nening; Merson, Sue; Hawkins, Steve; Howat, William; Lu, Yong-Jie; Lambert, Adam; Kay, Jonathan; Kremeyer, Barbara; Karaszi, Katalin; Camacho, Niedzica; Luxton, Hayley; Marsden, Luke; Edwards, Sandra; Matthews, Lucy; Bo, Valeria; Leongamornlert, Daniel; McLaren, Stuart; Ng, Anthony; Yu, Yongwei; Zhang, Hongwei; Dadaev, Tokhir; Thomas, Sarah; Easton, Douglas F.; Ahmed, Mahbubl; Bancroft, Elizabeth; Fisher, Cyril; Livni, Naomi; Nicol, David; Tavaré, Simon; Gill, Pelvender; Greenman, Christopher; Khoo, Vincent; Van As, Nicholas; Kumar, Pardeep; Ogden, Christopher; Cahill, Declan; Thompson, Alan; Mayer, Erik; Rowe, Edward; Dudderidge, Tim; Gnanapragasam, Vincent; Shah, Nimish C.; Raine, Keiran; Jones, David; Menzies, Andrew; Stebbings, Lucy; Teague, Jon; Hazell, Steven; Corbishley, Cathy; CamCaP Study Group; de Bono, Johann; Attard, Gerhardt; Isaacs, William; Visakorpi, Tapio; Fraser, Michael; Boutros, Paul C.; Bristow, Robert G.; Workman, Paul; Sander, Chris; The TCGA Consortium; Hamdy, Freddie C.; Futreal, Andrew; McDermott, Ultan; Al-Lazikani, Bissan; Lynch, Andy; Bova, G. Steven; Foster, Christopher S.; Brewer, Daniel S.; Neal, David E.; Cooper, Colin S.; Eeles, Rosalind A. (2018-04-16) - Journal article,

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer ...

Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal

Mitchell, Thomas J.; Turajlic, Samra; Rowan, Andrew; Nicol, David; Farmery, James H.R.; O’Brien, Tim; Martincorena, Inigo; Tarpey, Patrick; Angelopoulos, Nicos; Yates, Lucy R.; Butler, Adam P.; Raine, Keiran; Stewart, Grant D.; Challacombe, Ben; Fernando, Archana; Lopez, Jose I.; Hazell, Steve; Chandra, Ashish; Chowdhury, Simon; Rudman, Sarah; Soultati, Aspasia; Stamp, Gordon; Fotiadis, Nicos; Pickering, Lisa; Au, Lewis; Spain, Lavinia; Lynch, Joanna; Stares, Mark; Teague, Jon; Maura, Francesco; Wedge, David C.; Horswell, Stuart; Chambers, Tim; Litchfield, Kevin; Xu, Hang; Stewart, Aengus; Elaidi, Reza; Oudard, Stéphane; McGranahan, Nicholas; Csabai, Istvan; Gore, Martin; Futreal, P. Andrew; Larkin, James; Lynch, Andy G.; Szallasi, Zoltan; Swanton, Charles; Campbell, Peter J. (2018-04-19) - Journal article,

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...

Multi-part balanced incomplete-block designs

Bailey, Rosemary Anne; Cameron, Peter Jephson (2019-01-23) - Journal article,

We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some ...

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A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

Genomic evolution of breast cancer metastasis and relapse

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal

Multi-part balanced incomplete-block designs

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A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

Genomic evolution of breast cancer metastasis and relapse

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal

Multi-part balanced incomplete-block designs