Now showing items 11-20 of 25
The importance of DNA methylation in prostate cancer development
(2017-02) - Journal item,
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer
(2015-04-01) - Journal article,
Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
(2015-12-09) - Journal article,
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different ...
Mining human prostate cancer datasets : the “camcAPP” shiny app
(2017-03) - Journal item,
Multi-part balanced incomplete-block designs
(2019-01-23) - Journal article,
We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some ...
Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal
(2018-04-19) - Journal article,
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
(2017-08-29) - Journal article,
Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen ...
Telomerecat : a ploidy-agnostic method for estimating telomere length from whole genome sequencing data
(2018-01-22) - Journal article,
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented ...
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
(2017-09-25) - Journal article,
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
Mutational signatures of ionizing radiation in second malignancies
(2016-09-12) - Journal article,
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...