Now showing items 1-2 of 2
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy
(2017-06-01) - Journal article,
The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, ...
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
(2017-08-29) - Journal article,
Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen ...