Now showing items 1-4 of 4
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer
(2015-04-01) - Journal article,
Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study
(2015-09) - Journal article,
Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
(2015-12-09) - Journal article,
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different ...
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer
(2015-01) - Journal article,
Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations ...