Now showing items 1-3 of 3
Crambled : a Shiny application to enable intuitive resolution of conflicting cellularity estimates
(2015-12-07) - Journal article,
It is now commonplace to investigate tumour samples using whole-genome sequencing, and some commonly performed tasks are the estimation of cellularity (or sample purity), the genome-wide profiling of copy numbers, and the ...
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines
(2016-06-10) - Journal article,
Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate ...
Decomposition of mutational context signatures using quadratic programming methods
(2016-06-07) - Journal article,
Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...