Now showing items 1-5 of 5
Cholinekinase alpha as an androgen receptor chaperone and prostate cancer therapeutic target
(2016-05-01) - Journal article
Background: The androgen receptor (AR) is a major drug target in prostate cancer (PCa). We profiled the AR-regulated kinome to identify clinically relevant and druggable effectors of AR signaling. Methods: Using genome-wide ...
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer
(2015-04-01) - Journal article
Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1
(2016-09-07) - Journal article
New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
Telomerecat : a ploidy-agnostic method for estimating telomere length from whole genome sequencing data
(2018-01-22) - Journal article
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented ...
Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study
(2015-09) - Journal article
Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...