Now showing items 1-6 of 6
Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis
(2015-07-10) - Journal article,
Background: Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes. Results: While analysing whole genome paired-end sequencing of oesophageal adenocarcinomas ...
Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer
(2015-06-02) - Journal article,
Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene. Recent studies pointed to a consistent overexpression of MCT2 in prostate cancer (PCa) suggesting MCT2 as a putative biomarker ...
The early effects of rapid androgen deprivation on human prostate cancer
(2016-08) - Journal article,
The androgen receptor (AR) is the dominant growth factor in prostate cancer (PCa). Therefore, understanding how ARs regulate the human transcriptome is of paramount importance. The early effects of castration on human PCa ...
HES5 silencing is an early and recurrent change in prostate tumourigenesis
(2015-04-01) - Journal article,
Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...
Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1
(2016-09-07) - Journal article,
New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
(2017-08-29) - Journal article,
Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen ...