Now showing items 1-5 of 5
Crambled : a Shiny application to enable intuitive resolution of conflicting cellularity estimates
(2015-12-07) - Journal article,
It is now commonplace to investigate tumour samples using whole-genome sequencing, and some commonly performed tasks are the estimation of cellularity (or sample purity), the genome-wide profiling of copy numbers, and the ...
Decomposition of mutational context signatures using quadratic programming methods
(2016-06-07) - Journal article,
Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
Mining human prostate cancer datasets : the “camcAPP” shiny app
(2017-03) - Journal item,
Mutational signatures of ionizing radiation in second malignancies
(2016-09-12) - Journal article,
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...
Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study
(2015-09) - Journal article,
Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...