Now showing items 1-5 of 5
The role of TET-mediated DNA hydroxymethylation in prostate cancer
(2018-02-15) - Journal item,
Ten-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding that 5hmC is ...
DESNT : a poor prognosis category of human prostate cancer
(2018-12) - Journal article,
Background : A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis ...
Telomerecat : a ploidy-agnostic method for estimating telomere length from whole genome sequencing data
(2018-01-22) - Journal article,
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented ...
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
(2018-04-16) - Journal article,
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer ...
Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal
(2018-04-19) - Journal article,
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...