Now showing items 1-7 of 7
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy
(2017-06-01) - Journal article,
The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, ...
Mining human prostate cancer datasets : the “camcAPP” shiny app
(2017-03) - Journal item,
New model for estimating glomerular filtration rate in patients with cancer
(2017-08) - Journal article,
Purpose: The glomerular filtration rate (GFR) is essential for carboplatin chemotherapy dosing; however, the best method to estimate GFR in patients with cancer is unknown. We identify the most accurate and least biased ...
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
(2017-08-29) - Journal article,
Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen ...
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
(2017-09-25) - Journal article,
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
The importance of DNA methylation in prostate cancer development
(2017-02) - Journal item,
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
Genomic evolution of breast cancer metastasis and relapse
(2017-08-14) - Journal article,
Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...