Now showing items 1-5 of 5
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
(2015-12-09) - Journal article,
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different ...
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
(2017-09-25) - Journal article,
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
Mutational signatures of ionizing radiation in second malignancies
(2016-09-12) - Journal article,
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...
Genomic evolution of breast cancer metastasis and relapse
(2017-08-14) - Journal article,
Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
(2018-04-16) - Journal article,
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer ...