Now showing items 1-10 of 24
The role of TET-mediated DNA hydroxymethylation in prostate cancer
(2018-02-15) - Journal item,
Ten-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding that 5hmC is ...
Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal
(2018-04-19) - Journal article,
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer
(2015-06-02) - Journal article,
Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene. Recent studies pointed to a consistent overexpression of MCT2 in prostate cancer (PCa) suggesting MCT2 as a putative biomarker ...
Mining human prostate cancer datasets : the “camcAPP” shiny app
(2017-03) - Journal item,
Decomposition of mutational context signatures using quadratic programming methods
(2016-06-07) - Journal article,
Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1
(2016-09-07) - Journal article,
New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
Telomerecat : a ploidy-agnostic method for estimating telomere length from whole genome sequencing data
(2018-01-22) - Journal article,
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented ...
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
(2017-09-25) - Journal article,
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis
(2015-07-10) - Journal article,
Background: Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes. Results: While analysing whole genome paired-end sequencing of oesophageal adenocarcinomas ...
HES5 silencing is an early and recurrent change in prostate tumourigenesis
(2015-04-01) - Journal article,
Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...