Now showing items 1-10 of 14
Genomic evolution of breast cancer metastasis and relapse
(2017-08-14) - Journal article,
Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1
(2016-09-07) - Journal article,
New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines
(2016-06-10) - Journal article,
Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate ...
Decomposition of mutational context signatures using quadratic programming methods
(2016-06-07) - Journal article,
Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
Mining human prostate cancer datasets : the “camcAPP” shiny app
(2017-03) - Journal item,
The importance of DNA methylation in prostate cancer development
(2017-02) - Journal item,
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
(2015-03-19) - Journal article,
The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide ...
HES5 silencing is an early and recurrent change in prostate tumourigenesis
(2015-04-01) - Journal article,
Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...
DESNT : a poor prognosis category of human prostate cancer
(2017-03-06) - Journal article,
Background : A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis ...
New model for estimating glomerular filtration rate in patients with cancer
(2017-08) - Journal article,
Purpose: The glomerular filtration rate (GFR) is essential for carboplatin chemotherapy dosing; however, the best method to estimate GFR in patients with cancer is unknown. We identify the most accurate and least biased ...