Now showing items 1-10 of 50
Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics
(2018-01-14) - Journal article
Alternative sources of potential feedstock chemicals are of increasing importance as the availability of oil decreases. The biopolymer lignin is viewed as a source of useful mono-aromatic compounds as exemplified by the ...
Unprecedented strongly panchromic absorption from proton switchable iridium(III) azoimidazolate complexes
(2015-12) - Journal article
Two novel heteroleptic iridium(III) complexes bearing an aryldiazoimidazole ligand are reported. These complexes differ structurally with respect to the protonation state of the imidazole ring, but can be independently ...
6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis
(2017-02-28) - Journal article
The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea ...
Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
(2015-05-28) - Journal article
A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated ...
Selectively fluorinated cyclohexane building blocks : derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane
(2015-12-21) - Journal article
Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane ( 4 ) are illustrated as the start point for a variety of functional group interconversions. ...
Crystal structure resolution of two different chlorhexidine salts
(2016-10-05) - Journal article
Two salts of the chlorhexidine di-cation (H2CHx2+) – (H2CHx)(SO4)·3H2O and (H2CHx)(CO3)·4H2O – have been synthesised and characterised crystallographically.
Phosphorescent platinum(II) complexes bearing pentafluorosulfanyl substituted cyclometalating ligands
(2017-05-12) - Journal article
The first examples of phosphorescent platinum(II) complexes bearing pentafluorosulfanyl (-SF5) substituted cyclometalating ligands (C^N) are reported. These complexes are of the form [Pt(C^N)(pivacac)], where pivacac is ...
Enantioselective synthesis of 3,5,6-substituted dihydropyranones and dihydropyridinones using isothiourea-mediated catalysis
(2016-02-04) - Journal article
The scope of dihydropyranone and dihydropyridinone products accessible by isothiourea-catalysed processes has been expanded and explored through the use of 2-N-tosyliminoacrylates and 2-aroylacrylates in a Michael ...
Quinidine-Catalysed Enantioselective Synthesis of 6- and 4-Trifluoromethyl-Substituted Dihydropyrans
(2016-07) - Journal article
The cinchona alkaloid-catalysed enantioselective formal [4+2] cycloaddition of ethyl 2,3-butadienoate with a range of 1,1,1-trifluoro- and 4,4,4-trifluorobutenones is investigated for the preparation of stereodefined 6- ...
Chiral wide bite angle diphosphine ligands : synthesis, coordination chemistry and application in Pd-catalyzed allylic alkylation
(2015-05-11) - Journal article
A series of diphosphine ligands bearing ester- and ether-modified diphenylether backbones have been prepared. The introduction of carboxylic acid or ether auxiliaries in the ortho-positions relative to the diphenylphosphine ...