Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Steinig, Eike J; Andersson, Patiyan; Harris, Simon R; Sarovich, Derek S; Manoharan, Anand; Coupland, Paul; Holden, Matthew Tg; Parkhill, Julian; Bentley, Stephen D; Robinson, D Ashley; Tong, Steven Yc

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Date

16/05/2015

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.

Citation

Steinig , E J , Andersson , P , Harris , S R , Sarovich , D S , Manoharan , A , Coupland , P , Holden , M T , Parkhill , J , Bentley , S D , Robinson , D A & Tong , S Y 2015 , ' Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus ' , BMC Genomics , vol. 16 , 388 . https://doi.org/10.1186/s12864-015-1599-9

Publication

BMC Genomics

Status

Peer reviewed

DOI

https://doi.org/10.1186/s12864-015-1599-9

ISSN

1471-2164

Type

Journal article

Rights

© 2015 Steinig et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Description

YCT is an Australian National Health and Medical Research Council Career Development Fellow (1065736). DAR was supported in part by National Institutes of Health grant GM080602. SRH, PC, MTGH, JP and SDB were supported by Wellcome Trust grant 098051.

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/6676