Now showing items 1-6 of 6
Isothiourea-promoted O- to C-carboxyl transfer reactions
(University of St Andrews, 2011-11-30) - Thesis,
This thesis describes an extensive investigation of the O- to C-carboxyl transfer of oxazolyl carbonates using isothioureas as Lewis base catalysts. The structural requirements of simple bicyclic amidines and isothioureas ...
Mechanistic studies of azolium ions and their role in organocatalysis
(University of St Andrews, 2013) - Thesis,
This thesis describes our physical organic and mechanistic investigations into N Heterocyclic Carbene (NHC) mediated organocatalytic transformations, through a collaboration with the research group of Dr AnnMarie O’Donoghue ...
α,β-unsaturated acyl ammonium intermediates in asymmetric organocatalysis
(University of St Andrews, 2015-11-30) - Thesis,
This thesis details investigations into the generation and synthetic utility of α,β-unsaturated acyl ammonium intermediates using isothioureas as Lewis base organocatalysts to generate a range of heterocyclic products. Initial ...
NHCs in organocatalysis : azolium enolate generation and synthetic applications
(University of St Andrews, 2012-11-30) - Thesis,
This thesis details investigations into organocatalytic reactions promoted by N Heterocyclic Carbenes (NHCs) that proceed via an assumed azolium enolate intermediate. Initial research focused on the catalytic asymmetric ...
Enantioselective homogeneous catalysts for the synthesis of fluorinated organic compounds
(University of St Andrews, 2011-06) - Thesis,
This thesis is divided into three main results chapters that reflect the path my research took. In the first results chapter, the first organocatalyst for the carbonyl-ene reaction was discovered and found to give high ...
Lewis base-promoted organocatalysis : O- to C-carboxyl transfer reactions
(University of St Andrews, 2010-11-30) - Thesis,
This work describes the application of a variety of Lewis bases, encompassing predominantly N-heterocyclic carbenes (NHCs), but also the use of imidazoles, aminopyridines, amidines and isothioureas, as effective catalysts ...