Now showing items 1-9 of 9
Novel cambinol analogues as potential anticancer agents : an improved understanding of sirtuin isoform selectivity
(University of St Andrews, 2011-06-22) - Thesis
SIRT1 and SIRT2 are two NAD⁺-dependent deacetylases which negatively modulate the activity of p53, a protein which is involved in cell cycle arrest, senescence and apoptosis following genotoxic stress. Part I of the thesis ...
The search for allosteric inhibitors
(University of St Andrews, 2013-06-26) - Thesis
This thesis describes the development of chemical tools that inhibit the sialidases NanA and NanB from Streptococcus pneumonia. The primary focus was on the discovery of allosteric inhibitors of NanA and NanB, however, ...
Progress towards the synthesis of perophoramidine : formation of the contiguous quaternary centres
(University of St Andrews, 2013-06) - Thesis
Perophoramidine 1 is a halogenated natural product which contains two contiguous quaternary centres within its structure. In this thesis, approaches towards the synthesis of perophoramidine are described. In particular, ...
Chemical biology studies on 5-nitrofurans and sirtuin inhibitors
(University of St Andrews, 2012-12) - Thesis
Part I: Target identification studies are one of the most difficult but rewarding challenges in chemical biology. Part I of this thesis describes target identification studies for 5-nitrofuran containing hits. The ...
Use of the Claisen rearrangement in natural product synthesis
(University of St Andrews, 2018) - Thesis
The development of novel myosin inhibitors
(University of St Andrews, 2011-06) - Thesis
This thesis describes a structure activity relationship (SAR) study on the recently discovered small molecule tool blebbistatin (S)-21 with particular emphasis on the development of novel synthetic protocols suitable for ...
Using molecular oxygen in synthesis : applications in lignin valorisation and natural product synthesis
(University of St Andrews, 2015-06-24) - Thesis
The first part of this thesis describes my research towards the valorisation of lignin. Due to environmental and political pressures, there has been a drive to start the transition from a fossil fuel based economy to a ...
New methods for the diastereoselective construction of vicinal quaternary stereocenters and their application to the total synthesis of the bioactive (±)-dehalo-perophoramidine
(University of St Andrews, 2015) - Thesis
This thesis describes a novel total synthesis of (±)-dehalo-perophoramidine (a dehalogenated analogue of the natural product perophoramidine). The key synthetic transformation involves the construction of vicinal quaternary ...
(University of St Andrews, 2017-12-07) - Thesis