Now showing items 1-10 of 15
(University of St Andrews, 2018-06-27) - Thesis
Exploring the substrate scope of the fluorinase from Streptomyces cattleya for applications to positron emission tomography
(University of St Andrews, 2015-11-30) - Thesis
The fluorinase enzyme, originally isolated from Streptomyces cattleya, has the unique ability to generate a C–F bond from aqueous fluoride ion and S-adenosylmethionine, making the fluorinase an attractive biochemical tool ...
First syntheses of fluoromuscimols
(University of St Andrews, 2017-06-21) - Thesis
Chapter 1 provides a general introduction on the role of bioisosterism of fluorine aiming to improve the pharmacokinetics properties of lead compounds. GABAA receptors specifically, synaptic GABAA receptors, extrasynaptic ...
Effect of gem-difluorination on the conformation of selected hydrocarbon systems
(University of St Andrews, 2014-06-25) - Thesis
Owing to its unique electronic properties, the CF₂ group has the potential to affect the conformation and polarity of molecules. The Introduction provides an overview of the conformational effects induced by the incorporation ...
New approaches for C-F bond formation in organic chemistry
(University of St Andrews, 2010-06-23) - Thesis
The importance of fluorinated organic molecules has grown over the last 50 years, particularly in the pharmaceutical and agrochemical industries. Therefore the development of new methods for fluorination is a very attractive ...
Inhibition studies of kynurenine 3-monooxygenase
(University of St Andrews, 2013-11-29) - Thesis
Kynurenine 3-monooxygenase (K3MO) lies on the kynurenine pathway, the major pathway for the catabolism of L-tryptophan. It converts kynurenine to 3-hydroxy kynurenine. Inhibition of K3MO is important in several neurological ...
Identification and enzyme studies of rare amino acid biosynthesis from Streptomyces cattleya
(University of St Andrews, 2013) - Thesis
This thesis is focussed on the biosynthesis of three toxins: fluoroacetate, 4-fluoro-L-theronine and β-ethynyl-L-serine which are biosynthesised by the soil bacteria Streptomyces cattleya. The two fluorinated metabolites ...
The C-F bond as a conformational probe in agonist receptor interactions.
(University of St Andrews, 2012-06-20) - Thesis
Chapter 1 gives an introduction on the physical and electronic properties of fluorine and the C-F bond. The application of fluorine in organic chemistry, which is mainly attributed to the electronic properties of fluorine ...
Selective incorporation of the C-F bond as a conformational tool in quadruplex DNA ligand design
(University of St Andrews, 2012-08-15) - Thesis
Chapter 1 provides a general introduction to organofluorine chemistry and focuses on recent developments in fluorination techniques. It also details how the C–F bond influences conformational and physiochemical properties ...
Stereospecific dehydroxyfluorination and the synthesis of trifluoro D-hexose sugar analogues
(University of St Andrews, 2011-06-22) - Thesis
This thesis describes stereospecific fluorination reactions, and addresses the synthesis of fluorosugars. In Chapter 1, the influence of fluorine on the physical properties of organic molecules, as well as its stereoelectronic ...