Now showing items 1-6 of 6
Synthesis and evaluation of α-fluoro analogues of capsaicin and 2-(aminomethyl)piperidine derivatives
(University of St Andrews, 2011-08-09) - Thesis,
Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine ...
Selective incorporation of the C-F bond as a conformational tool in quadruplex DNA ligand design
(University of St Andrews, 2012-08-15) - Thesis,
Chapter 1 provides a general introduction to organofluorine chemistry and focuses on recent developments in fluorination techniques. It also details how the C–F bond influences conformational and physiochemical properties ...
Exploring the substrate scope of the fluorinase from Streptomyces cattleya for applications to positron emission tomography
(University of St Andrews, 2015-11-30) - Thesis,
The fluorinase enzyme, originally isolated from Streptomyces cattleya, has the unique ability to generate a C–F bond from aqueous fluoride ion and S-adenosylmethionine, making the fluorinase an attractive biochemical tool ...
The vicinal difluoro motif in organic chemistry : the synthesis and behaviour of compounds derived from 2,3-diflurosuccinic acids
(University of St Andrews, 2006) - Thesis,
The following work describes the synthesis of compounds carrying a vicinal difluoro motif and the evaluation of this structural element to influence the conformation of organic molecules. The synthesis of erythro and ...
The C-F bond as a conformational probe in agonist receptor interactions.
(University of St Andrews, 2012-06-20) - Thesis,
Chapter 1 gives an introduction on the physical and electronic properties of fluorine and the C-F bond. The application of fluorine in organic chemistry, which is mainly attributed to the electronic properties of fluorine ...
First syntheses of fluoromuscimols
(University of St Andrews, 2017-06-21) - Thesis,
Chapter 1 provides a general introduction on the role of bioisosterism of fluorine aiming to improve the pharmacokinetics properties of lead compounds. GABAA receptors specifically, synaptic GABAA receptors, extrasynaptic ...