Now showing items 1-5 of 5

    • Asymmetric synthesis of amino acid derivatives as molecular probes for the mechanism of 3-methylaspsartate ammonia-lyase 

      Lasry, Philippe (University of St Andrews, 1998) - Thesis
      3-Methylaspartate ammonia-lyase is a bacterial enzyme that catalyses the reversible elimination of ammonia, in the presence of monovalent and divalent metal ions, from (2S,3S)-3-methylaspartic acid to yield mesaconic acid. ...
    • Mechanistic studies on threonine synthase 

      Barclay, Fiona (University of St Andrews, 1995) - Thesis
      Threonine synthase catalyses the conversion of (2S)-0-phosphohomoserine to (2S,3R)-threonine with the elimination of phosphate. A novel and efficient synthesis of (2S)-0-phosphohomoserine has been developed starting from ...
    • Peptide secondary structure mimetics: The alpha-helix and beta-turn 

      Arwel, Lewis (University of St Andrews, 1998) - Thesis
      This thesis describes research undertaken in peptidomimetic chemistry, concerned with stabilisation of peptide secondary structure. The first section describes the successful synthesis of two triazepinediones for potential ...
    • Studies on threonine synthase 

      Neal, Tracy (University of St Andrews, 1998) - Thesis
      Threonine synthase (TS, EC 4.2.99.2), catalyses a β,γ-replacement reaction to convert (2S)-0-phosphohomoserine (32) into (2S,3S)-threonine (33). Although threonine as an essential amino acid is vital to all lifeforms, the ...
    • Synthetic and structural studies of foot-and-mouth disease virus polyprotein processing 

      Lenman, Morag May (University of St Andrews, 1996) - Thesis
      The 2A region of the foot-and-mouth disease virus (FMDV) polyprotein is only 16 amino acids in length. During synthesis of the FMDV polyprotein, a primary proteolytic processing event occurs between the 2A and 2B regions ...