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Theiler's murine encephalomyelitis protein 2C and its effect on membrane trafficking
(University of St Andrews, 2008) - Thesis,
Picornaviruses replicate in association with cytoplasmic membranes of infected cells.
Poliovirus 2C and 2BC play an important role in the formation of membranous vesicles, and
induce dramatic changes in membrane trafficking. ...
Functional analysis of the orthobunyavirus nucleocapsid (N) protein
(University of St Andrews, 2008) - Thesis,
Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae. It has a
tripartite genome consisting of negative sense RNA segments called large (L),
medium (M) and small (S). The S segment encodes the nucleocapsid ...
Studies on influenza A virus PB1-F2 protein
(University of St Andrews, 2011-11-30) - Thesis,
The influenza A virus genome codes for up to 12 proteins. Segment 2 encodes three proteins, the polymerase subunit PB1, a small protein PB1-F2 and an N-terminally truncated version of PB1 called N40. Different functions ...
Development of a novel cell-based screening platform to identify inhibitors of viral interferon antagonists from clinically important viruses
(University of St Andrews, 2016) - Thesis,
All viruses encode for at least one viral interferon (IFN) antagonist, which is
used to subvert the cellular IFN response, a powerful antiviral innate immune response.
Numerous in vitro and in vivo studies have demonstrated ...
Molecular studies of the Tacaribe virus nucleoprotein (NP): identification and characterisation of virus-host interactions as novel anti-arenavirus drug targets
(University of St Andrews, 2014) - Thesis,
Arenaviruses cause an estimated 300,000 – 500,000 infections annually. Currently there is no arenavirus-specific antiviral drug available to treat these infections. This study sought to use the non-pathogenic New World ...
Structural studies of bunyavirus interferon antagonist proteins
(University of St Andrews, 2016-06-22) - Thesis,
Bunyaviridae is one of the biggest known viral families, and includes many viruses of clinical and economic importance. The major virulence factor of most bunyaviruses is the non-structural protein (NSs). NSs is expressed ...