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Viral interferon antagonists and antiviral drugs
(University of St Andrews, 2009-11-30) - Thesis,
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs. The viral proteins expressed ...
Virus and interferon : a fight for supremacy : comparison of the mechanisms of influenza A viruses and parainfluenza virus 5 in combatting a pre-existing IFN-induced antiviral state
(University of St Andrews, 2011-06-06) - Thesis,
The Interferon (IFN) family of cytokines are produced in direct response to virus infection and they constitute the first line of defence against virus infection by inducing hundreds of interferon stimulated genes (ISGs) ...
Interferon, virus vaccines and antiviral drugs
(University of St Andrews, 2008-06) - Thesis,
The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross
species barriers to infect unnatural hosts, poses a huge threat to humans. It is therefore
essential to develop new methodologies ...
Impact of interferon β and interferon stimulated gene induction on Bunyamwera virus replication
(University of St Andrews, 2012-06-20) - Thesis,
The first line of defence against viral infection is the interferon (IFN) response, which must be overcome by a virus for successful replication. Pattern recognition receptors detect virus which triggers induction of IFNβ. ...
The effect of interferon on the transcription pattern of parainfluenza virus 5
(University of St Andrews, 2013-06-26) - Thesis,
Interferon (IFN) is activated in response to virus infections and upregulates interferon-stimulated genes (ISGs) resulting in the expression of hundreds of proteins, many of which have direct or indirect antiviral activity. ...
Studies on interferon (IFN) induction and isolation of IFN-inducing mutant viruses
(University of St Andrews, 2011-06) - Thesis,
The interferon (IFN) system is a powerful antiviral defense system. Host cell pattern recognition receptors (PRRs) recognise pathogen-associated molecule patterns (PAMPs) which when activated, lead to the transcription of ...
Investigating the antiviral activity of the interferon-inducible GTPase MxA against influenza viruses
(University of St Andrews, 2016-06-22) - Thesis,
The interferon (IFN) system forms an essential part of the innate immune response,
up-regulating hundreds of IFN-stimulated genes (ISGs) in response to viral infection.
A key protein in this response is the human myxovirus ...
Interferon, viruses and drug discovery
(University of St Andrews, 2017-06-21) - Thesis,
The interferon (IFN) response is a crucial component of cellular innate immunity, vital for controlling virus infections. Dysregulation of the IFN response however can lead to serious medical conditions including autoimmune ...
Molecular studies of the Tacaribe virus nucleoprotein (NP): identification and characterisation of virus-host interactions as novel anti-arenavirus drug targets
(University of St Andrews, 2014) - Thesis,
Arenaviruses cause an estimated 300,000 – 500,000 infections annually. Currently there is no arenavirus-specific antiviral drug available to treat these infections. This study sought to use the non-pathogenic New World ...
Interferon induction by paramyxoviruses : investigations into specific RNA:protein interactions
(University of St Andrews, 2017-06-21) - Thesis,
RNA:protein interactions are central in many cellular processes, including activation of innate immune responses against microbial infection. Their study is essential to better understand the diverse biological events that ...