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Influenza A viruses and PI3K signalling
(University of St Andrews, 2007-09-28) - Thesis,
The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell
processes. This study reports that NS1 binds directly ...
An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle
(University of St Andrews, 2007-11-30) - Thesis,
Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive ...
Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP
(University of St Andrews, 2013-06-26) - Thesis,
The mechanism of body and organ size control is an unsolved puzzle. Initially characterized in Drosophila melanogaster, the Salvador/Warts/Hippo (Hippo) signalling pathway, highly conserved throughout evolution, defines a ...
Willin as a novel 4.1 ezrin radixin moesin (FERM) domain protein in the mammalian hippo signalling pathway
(University of St Andrews, 2011-11-30) - Thesis,
The Salvador/Warts/Hippo (Hippo) pathway defines a novel signalling cascade regulating cell contact inhibition, organ size control, cell growth, proliferation, apoptosis and cancer development in mammals. The Hippo pathway ...
New intracellular mechanisms involved in Alzheimer's disease and frontotemporal dementia
(University of St Andrews, 2012-06-20) - Thesis,
Dementia causes an increasing social and economic burden worldwide, demanding action regarding its diagnosis, treatment and everyday management. Recent years have seen many advances in neurodegeneration research, but the ...