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An investigation of the ABAD-Aβ interaction as a potential therapeutic target for the treatment of Alzheimer’s disease
(University of St Andrews, 2011-06) - Thesis,
Alzheimer’s disease (AD) is the leading cause of dementia but despite being
identified over a century ago, current treatments remain limited. To date, no disease-modifying therapies are available.
Soluble, intracellular ...
Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products
(University of St Andrews, 2008-10-27) - Thesis,
Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD ...
New intracellular mechanisms involved in Alzheimer's disease and frontotemporal dementia
(University of St Andrews, 2012-06-20) - Thesis,
Dementia causes an increasing social and economic burden worldwide, demanding action regarding its diagnosis, treatment and everyday management. Recent years have seen many advances in neurodegeneration research, but the ...
The identification and characterisation of novel inhibitors of the 17β-HSD10 enzyme for the treatment of Alzheimer's disease
(University of St Andrews, 2016-11) - Thesis,
In 2015, an estimated 46.8 million people were living with dementia, a number predicted to increase to 74.7 million by 2030 and 131.5 million by 2050. Whilst there are numerous causes for the development of dementia, ...
Investigating protein- protein interactions in order to develop novel therapeutics for the treatment of Alzheimer’s disease
(University of St Andrews, 2013-06-26) - Thesis,
Alzheimer’s disease (AD) accounts for around two thirds of all dementia cases and an increase in life expectancy of the population has resulted in a substantial increase in dementia cases and with that a rise in AD. AD is ...