Now showing items 1-15 of 15

    • Boron-containing compounds as inhibitors of HIV proteinase 

      McNab, Donald (University of St Andrews, 1997) - Thesis
      HIV Proteinase (HIV PR) has proved to be an excellent target for the development of anti-AIDS drugs. Four inhibitors of this enzyme are now approved for clinical use but they, like others, suffer from shortcomings associated ...
    • Design and synthesis of inhibitors for the HIV-1 protease 

      Camp, Nicholas Paul (University of St Andrews, 1994) - Thesis
      A variety of phosphonamidate-containing peptides were synthesised as potential inhibitors of the HIV-1 protease. These transition state analogues were designed using known sequences from HIV-1 protease substrates and ...
    • Design and synthesis of phosphorus-based inhibitors for the HIV-1 proteinase 

      Perrey, David Alan (University of St Andrews, 1995) - Thesis
      A number of peptide fragments including (2S)-Pro-(2S)-Ile-NHiBu (72) and (2S)-Phe-(2S)-Ile-NHiBu (73) and l-(benzyloxycarbonyl)-aminophosphinic acid methyl esters (analogues of Phe (76), Cha (77) and Leu (78)) have been ...
    • An investigation into the catalytic mechanism of the adenovirus type II proteinase 

      Cornish, Julie Anne. (University of St Andrews, 1996) - Thesis
      A series of P4 (Cbz and t-Boc) N-protected potential substrates and inhibitors, containing the P1 to P4 substrate recognition sequence of the type 2 adenovirus proteinase (Leu-Ala-Gly-Gly) were prepared by solution phase ...
    • Mechanistic and stereochemical studies on methylaspartase and glutamate mutase 

      Archer, Catherine Helen (University of St Andrews, 1993) - Thesis
      Preliminary studies have been undertaken on the enzyme, glutamate mutase. Stereochemically pure (2S,3S)-3-ethylaspartic acid has been synthesized. The turnover of this substrate analogue by glutamate mutase has been ...
    • Mechanistic and structural studies on myo-inositol monophosphatase: the emerging target for lithium therapy 

      Pybus, Roger David (University of St Andrews, 1998) - Thesis
      Enzymic phosphate monoester hydrolysis by myo-inositol monophosphatase from bovine brain (EC.3.1.3.25) has been shown to occur via the direct displacement of phosphate by water rather than by a two step mechanism involving ...
    • Mechanistic studies on glutamate decarboxylase and serine hydroxmethyltransferase 

      Rose, Janet Elizabeth (University of St Andrews, 1993) - Thesis
      (2S)- and (2R)-Serine O-sulphate have been synthesised and shown to inactivate glutamate decarboxylase (GAD) from E. Coli. Novel methodology was developed to enable the stereospecific synthesis of (2S) and (2R)-deuteriated ...
    • Mechanistic studies on glutamate mutase 

      Hartzoulakis, Basil (University of St Andrews, 1994) - Thesis
      The coenzyme B12-dependent enzyme glutamate mutase (E.C. 5.4.99.1) catalyses the rearrangement of (2S)-glutamic acid to (2S,3S)-3-methylaspartic acid. Each of the two components of the enzyme was purified to homogeneity ...
    • Mechanistic studies on myo-inositol monophosphatase 

      Cole, Andrew Graham (University of St Andrews, 1994) - Thesis
      Enzymic phosphate monoester hydrolysis by inositol monophosphatase from bovine brain (EC 3.1.3.25) occurs via the direct displacement of phosphate by water rather than by a two step mechanism involving a phosphorylated ...
    • Stereochemical and mechanistic studies on the aspartic proteases 

      Hawkins, Paul Charles David (University of St Andrews, 1993) - Thesis
      A series of experiments, designed to investigate two mutually incompatible theories of the catalysis carried out by pepsin, the archetypal aspartic protease, were undertaken. Mechanism-activated active-site probes, based ...
    • A study of the 2A region of aphthoviruses 

      Donnelly, Michelle L. L. (University of St Andrews, 1997) - Thesis
      The proteins encoded by foot-and-mouth disease virus are expressed in the form of a polyprotein, which is processed by virus-encoded proteases to yield the mature viral proteins. The focus of this thesis is the 18 amino ...
    • Synthesis and evaluation of enzyme inhibitors based on amino- and cyclopropane carboxylic acids 

      Badiani, Kamal (University of St Andrews, 1997) - Thesis
      The coenzyme B12-dependent enzyme, glutamate mutase (E. C. 5.4.99.1), catalyses the reversible carbon-skeleton rearrangement of (2S)-glutamic acid to (25.35)-3-methylaspartic acid. Glutamate mutase is the first enzyme on ...
    • Synthesis of nodularin analogues as potential protein phosphatases inhibitors 

      Webster, Kerri Lesley (University of St Andrews, 1998) - Thesis
      Reversible phosphorylation of proteins on serine, threonine and tyrosine residues, is now widely accepted to be the principal mechanism for the control of intracellular events in eukaryotic and prokaryotic cells. The ...
    • Synthesis of potential substrates and inhibitors for pyridoxal-phosphate dependent enzymes 

      Khayer, Khurshida (University of St Andrews, 1997) - Thesis
      Pyridoxal 5'-phosphate dependent aspartate aminotransferase catalyses the conversion of (2S)-aspartic acid and a-ketoglutaric acid into (2S)-glutamic acid and oxaloacetate. Both the mono and dimethylesters of (2S)-aspartic ...
    • Synthetic studies on the adenovirus serotype 2 L3 23 kDa proteinase 

      Cromie, Thomas James (University of St Andrews, 1996) - Thesis
      This Thesis details research undertaken on the continuing project investigating the novel catalytic mechanism of the adenovirus serotype 2 L3 23 kDa proteinase. The proteinase is a virally encoded endopeptidase which is ...