Now showing items 21-30 of 46
Organo-fluorine chemistry III
(2013-10-23) - Journal item,
Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement
(2005-10-17) - Journal article,
Background: Asymmetric introduction of fluorine alpha- to a carbonyl has become popular recently, largely because the direct fluorination of enolates by asymmetric electrophilic fluorinating reagents has improved, and as ...
Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme
(2015) - Journal article,
The investigation of a difluoromethyl-bearing nucleoside with the fluorinase enzyme is described. 5’,5’–Difluoro-5’-deoxyadenosine 7 (F2DA) was synthesised from adenosine, and found to bind to the fluorinase enzyme by ...
Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes
(2016-01-21) - Journal article,
This paper reports the preparation of methyl substituted all-cis tetrafluorocyclohexanes prepared from a Birch reduction of benzoic acid, worked up with a methyl iodide quench. The resultant methylcyclohexadiene carboxylic ...
Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
(2017-09) - Journal article,
Scope : The physiological relevance of contemporary cell culture studies is often perplexing, given the use of unmetabolized phytochemicals at supraphysiological concentrations. We investigated the activity of physiologically ...
The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes
(2012-08-10) - Journal article,
Cyclododecane adopts a square-like structure with corner and edge CH2 groups. In this study erythro- and threo-1,2-difluorocyclododecanes were prepared to explore whether the two vicinal C-F bonds, with different relative ...
Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications
(2016-11-14) - Journal article,
This paper explores the synthesis of a series of prototype negative dielectric liquid crystalline (LC) compounds which contain fluorinated cyclohexane motifs. The series are analogues and differ only in that they contain ...
Fluorinated musk fragrances : the CF2 group as a conformational bias influencing the odour of civetone and (R)-muscone
(2016-06-06) - Journal article,
The difluoromethylene (CF2) group has a strong tendency to adopt corner over edge locations in aliphatic macrocycles. In this study, the CF2 group has been introduced into musk relevant macrocyclic ketones. Nine civetone ...
Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane
(2016-04-14) - Journal article,
The all-cis isomer of 1,2,3,4-tetrafluorocyclopentane is prepared and characterised by NMR and X-ray crystallography and the experimental structure compared with theory. The structure has a similarly high polarity to all-cis ...
Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
(2015-05-28) - Journal article,
A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated ...