Now showing items 11-20 of 46
Janus face aspect of all-cis 1,2,3,4,5,6-hexafluorocyclohexane dictates remarkable anion and cation interactions in the gas phase
(2016-06-22) - Journal article,
Experiments have been carried out in which electrospray ionization has been used to generate ionic complexes of all-cis 1,2,3,4,5,6 hexafluorocyclohexane. These complexes were subsequently mass isolated in a quadrupole ion ...
Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus
(2017-01-07) - Journal article,
Deuterium and carbon-13 labelled glycerols have been fed to Streptomyces calvus fermentations and isotope incorporation into the fluorine containing antibiotic nucleocidin have been evaluated by 19F-NMR. A single deuterium ...
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
(2016-07-25) - Journal article,
We report a last-step fluorinase-catalyzed [18F]-fluorination of a cysteine-containing RGD peptide. The peptide was attached through sulfur to a modified and more hydrophilic variant of the recently disclosed Barbas linker ...
Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs : a gas-phase C–C bond-forming reaction on a surface
(2014-05-20) - Journal article,
Vinyl-terminated self-assembled monolayers (SAMs) on silicon oxide substrates were chemically modified by the addition of a bis(trifluoromethyl)methylene group in a rare gas-phase C–C bond-forming reaction to directly ...
Synthesis of selectively fluorinated cyclohexanes : the observation of phenonium rearrangements during deoxyfluorination reactions on cyclohexane rings with a vicinal phenyl substituent
(2015) - Journal article,
A study focused on the synthesis of a derivative of all-cis phenyl-2,3,5,6-tetrafluorocyclohexane, incorporating a methyl group at the benzylic position, found that the fluorination reactions of diepoxide and diol precursors, ...
Themed series in organo-fluorine chemistry
(2008-04-25) - Journal item,
Organo-fluorine chemistry II
(2010-04-20) - Journal item,
Single enantiomer synthesis of alpha-(trifluoromethyl)-beta-lactam
(2011-06-06) - Journal article,
The first synthesis of alpha-(trifluoromethyl)-beta-lactam ((S)-1) is reported. The route starts from alpha-(trifluoromethyl)acrylic acid (2). Conjugate addition of alpha-(p-methoxyphenyl)ethylamine ((S)-3b), generated an ...
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
(2009-07-27) - Journal article,
The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose ...
Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
(2009-11-05) - Journal article,
A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three ...