Now showing items 1-10 of 37
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis
(2015-03-23) - Journal article,
Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products. Despite the fact that members of this sub-family act as protein-protein interaction ...
A core switching strategy to pyrrolo[2,3-b]quinolines and diazocino[1,2-a]indolinones
(2016-10-14) - Journal article,
Two novel core-switching rearrangements to natural product-like privileged scaffolds that proceed in up to 99% yield have been developed. The deviation away from planarity of the central N-acyl urea carbonyl, caused by the ...
Synthesis of selectively fluorinated cyclohexanes : the observation of phenonium rearrangements during deoxyfluorination reactions on cyclohexane rings with a vicinal phenyl substituent
(2015) - Journal article,
A study focused on the synthesis of a derivative of all-cis phenyl-2,3,5,6-tetrafluorocyclohexane, incorporating a methyl group at the benzylic position, found that the fluorination reactions of diepoxide and diol precursors, ...
Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement
(2005-10-17) - Journal article,
Background: Asymmetric introduction of fluorine alpha- to a carbonyl has become popular recently, largely because the direct fluorination of enolates by asymmetric electrophilic fluorinating reagents has improved, and as ...
Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes
(2016-01-21) - Journal article,
This paper reports the preparation of methyl substituted all-cis tetrafluorocyclohexanes prepared from a Birch reduction of benzoic acid, worked up with a methyl iodide quench. The resultant methylcyclohexadiene carboxylic ...
Electrochemically informed synthesis : oxidation versus coordination of 5,6-Bis(phenylchalcogeno)acenaphthenes
(2013-10-07) - Journal article,
Isothiourea-catalysed enantioselective pyrrolizine synthesis : synthetic and computational studies
(2016-10-14) - Journal article,
The catalytic enantioselective synthesis of a range of cis-pyrrolizine carboxylate derivatives with outstanding stereocontrol (14 examples,>95:5 dr, >98:2 er) through an isothiourea-catalyzed intramolecular Michael ...
Enantioselective stereodivergent nucleophile-dependent isothiourea-catalysed domino reactions
(2016-12-05) - Journal article,
α,β-Unsaturated acyl ammoniums generated from the reaction of α,β-unsaturated 2,4,6-trichlorophenol (TCP) esters bearing a pendent enone with an isothiourea organocatalyst are versatile intermediates in a range of ...
Neutral iodotriazoles as scaffolds for stable halogen-bonded assemblies in solution
(2016-10-01) - Journal article,
The halogen bond (XB) donor properties of neutral 1,4-diaryl-5-iodo-1,2,3-triazoles, are explored using a combination of computational and experimental results and are shown to be competitive in halogen bonding efficiency ...
Enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofurans using a Brønsted base/thiourea bifunctional catalyst
(2016-08-14) - Journal article,
The diastereo- and enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofuran derivatives (15 examples, up to 96:4 dr, 95:5 er) via intramolecular Michael addition has been developed using keto-enone ...