Now showing items 1-10 of 46
All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarised cyclohexane
(2015-04) - Journal article,
The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, in which all of the fluorines are ‘up’, is prepared in a 12-step protocol. The molecule adopts a classic chair conformation with alternate C–F bonds ...
Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs : a gas-phase C–C bond-forming reaction on a surface
(2014-05-20) - Journal article,
Vinyl-terminated self-assembled monolayers (SAMs) on silicon oxide substrates were chemically modified by the addition of a bis(trifluoromethyl)methylene group in a rare gas-phase C–C bond-forming reaction to directly ...
Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
(2015-05-28) - Journal article,
A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated ...
Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks
(2014-09-11) - Journal article,
Intramolecular CF···FC interactions in selected organofluorine compounds (all-syn-1,2,3,4- and all-syn-1,2,4,5-tetrafluorocyclohexane, 1,8-difluoronaphthalene, 4,5-difluorophenanthrene, 2,2′,5,5′-tetrafluorobiphenyl) were ...
Synthesis of selectively fluorinated cyclohexanes : the observation of phenonium rearrangements during deoxyfluorination reactions on cyclohexane rings with a vicinal phenyl substituent
(2015) - Journal article,
A study focused on the synthesis of a derivative of all-cis phenyl-2,3,5,6-tetrafluorocyclohexane, incorporating a methyl group at the benzylic position, found that the fluorination reactions of diepoxide and diol precursors, ...
A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography
(2015-09-11) - Journal article,
A two-step radiolabelling protocol of a cancer relevant cRGD peptide is described where the fluorinase enzyme is used to catalyse a transhalogenation reaction to generate [18F]-5'-fluoro-5'-deoxy-2-ethynyladenosine, ...
Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane
(2016-04-14) - Journal article,
The all-cis isomer of 1,2,3,4-tetrafluorocyclopentane is prepared and characterised by NMR and X-ray crystallography and the experimental structure compared with theory. The structure has a similarly high polarity to all-cis ...
Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications
(2016-11-14) - Journal article,
This paper explores the synthesis of a series of prototype negative dielectric liquid crystalline (LC) compounds which contain fluorinated cyclohexane motifs. The series are analogues and differ only in that they contain ...
Themed series in organo-fluorine chemistry
(2008-04-25) - Journal item,
Organo-fluorine chemistry II
(2010-04-20) - Journal item,