Now showing items 1-4 of 4
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
(2009-07-27) - Journal article,
The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose ...
Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
(2009-11-05) - Journal article,
A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three ...
Iso-seco-tanapartholides : isolation, synthesis and biological evaluation
(2009-11) - Journal article,
The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient ...
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH
(2009-05-19) - Journal article,
Background: Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment ...