Now showing items 1-4 of 4
The difluoromethylene (CF2) group in aliphatic chains : synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups
(2014-01-06) - Journal article,
The syntheses of palmitic acids and a nonadecane are reported with CF2 groups located 1,3 or 1,4 to each other along the aliphatic chain. Specifically 8,8,10,10- and 8,8,11,11-tetrafluorohexadecanoic acids (6b and 6c) are ...
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase
(2016-03-21) - Journal article,
The substrate scope of fluorinase enzyme mediated transhalogenation reactions is extended. Substrate tolerance allows a peptide cargo to be tethered to a 5'-chloro-5'-deoxynucleoside substrate for transhalogenation by the ...
Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
(2009-11-05) - Journal article,
A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three ...
The synthesis and evaluation of fluoro-, trifluoromethyl, and iodomuscimols as GABA agonists
(2017-08-10) - Journal article,
Halogenated analogues of the neurotoxic alkaloid muscimol were prepared with fluorine, iodine or trifluoromethyl at the 4 position of the isoxazole ring system. These compounds were investigated as agonists for GABAA ...