Now showing items 1-4 of 4
A novel class of fluorinated A2A adenosine receptor agonist with application to last step enzymatic [18F]fluorination for PET imaging
(2017-11-02) - Journal article,
The A2A adenosine receptor belongs to a family of G-coupled protein receptors that have been subjected to extensive investigation over the last few decades. Due to their prominent role in the biological functions of the ...
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
(2009-07-27) - Journal article,
The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose ...
Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme
(2015) - Journal article,
The investigation of a difluoromethyl-bearing nucleoside with the fluorinase enzyme is described. 5’,5’–Difluoro-5’-deoxyadenosine 7 (F2DA) was synthesised from adenosine, and found to bind to the fluorinase enzyme by ...
A localised tolerance in the substrate specificity of the fluorinase enzyme enables "last step" 18F fluorination of a RGD peptide under ambient aqueous conditions
(2014-08-18) - Journal article,
A strategy for last-step 18F fluorination of bioconjugated peptides is reported that exploits an “Achilles heel” in the substrate specificity of the fluorinase enzyme. An acetylene functionality at the C-2 position of the ...