Now showing items 1-10 of 30
Advanced light-sheet and structured illumination microscopy techniques for neuroscience and disease diagnosis
(University of St Andrews, 2016-11-30) - Thesis
Optical techniques for the investigation of a mechanical role for FRMD6/Willin in the Hippo signalling pathway
(University of St Andrews, 2019-06-24) - Thesis
The mammalian hippo signalling pathway controls cell proliferation and apoptosis via transcriptional co-activators YAP and TAZ, and as such is a key regulator of organ and tissue growth. Multiple cellular components ...
Tailoring optical fibers for cell transfection
(University of St Andrews, 2012-11-30) - Thesis
Optical transfection is a promising technique for the delivery of foreign genetic material into cells by transiently changing the permeability of the cell membrane. Of the different optical light sources that have been ...
Studies of novel beam shapes and applications to optical manipulation
(University of St Andrews, 2010-11-30) - Thesis
In this thesis an investigation into novel beams and optical manipulation is presented. Sculpting the phase profile of a Gaussian beam can result in the generation of a beam with unusual properties. Described in this thesis ...
Advanced multimodal methods in biomedicine : Raman spectroscopy and digital holographic microscopy
(University of St Andrews, 2017-12-07) - Thesis
Moving towards label-free technologies is essential for many clinical and research applications. Raman spectroscopy is a powerful tool in the field of biomedicine for label-free cell characterisation and disease diagnosis, ...
Photoporation and optical manipulation of plant and mammalian cells
(University of St Andrews, 2015-06-24) - Thesis
Optical cell manipulation allows precise and non-invasive exploration of mammalian cell function and physiology for medical applications. Plants, however, represent a vital component of the Earth’s ecosystem and the knowledge ...
Optical micromanipulation using dispersion-compensated and phase-shaped ultrashort pulsed lasers
(University of St Andrews, 2009-11-30) - Thesis
Ultrashort pulsed lasers offer high peak powers at low average powers, making them ideal for maximising the efficiency of nonlinear excitation. Their broad bandwidths make it possible to tailor the pulse's temporal profile ...
Experimental studies of cold atom guiding using hollow light beams
(University of St Andrews, 2005) - Thesis
This thesis is concerned with the guiding of cold atoms using optical forces, which is of great importance in the field of atom optics. Atomic beams can be used for precision sensor equipment, building nano-scale structures, ...
Applications of microfluidic chips in optical manipulation & photoporation
(University of St Andrews, 2010-10-01) - Thesis
Integration and miniaturisation in electronics has undoubtedly revolutionised the modern world. In biotechnology, emerging lab-on-a-chip (LOC) methodologies promise all-integrated laboratory processes, to perform complete ...
Integration methods for enhanced trapping and spectroscopy in optofluidics
(University of St Andrews, 2011-12) - Thesis
“Lab on a Chip” technologies have revolutionized the field of bio-chemical analytics. The crucial role of optical techniques in this revolution resulted in the emergence of a field by itself, which is popularly termed as ...