Now showing items 1-20 of 165

    • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

      Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
      This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...
    • Adapting to time : duration channels do not mediate human time perception 

      Curran, WIlliam; Benton, Christopher; Harris, Julie; Hibbard, Paul Barry; Beattie, L (2016-03) - Journal article
      Accurately encoding the duration and temporal order of events is essential for survival and important to everyday activities, from holding conversations to driving in fast-flowing traffic. Although there is a growing body ...
    • Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice 

      Witts, Emily Charlotte; Nascimento, Filipe; Miles, Gareth Brian (2015-10) - Journal article
      Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS, including motor control ...
    • All-optical assay to study biological neural networks 

      Afshar Saber, Wardiya; Gasparoli, Federico M.; Dirks, Marjet Gabrielle; Gunn-Moore, Frank J.; Antkowiak, Maciej (2018-07-05) - Journal article
      We introduce a novel all-optical assay for functional studies of biological neural networks in vitro. We created a novel optogenetics construct named OptoCaMP which is a combination of a channelrhodopsin variant (CheRiff) ...
    • Assessing host-virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes 

      Madinda, Nadège F.; Ehlers, Bernhard; Wertheim, Joel O.; Akoua-Koffi, Chantal; Bergl, Richard A.; Boesch, Christophe; Akonkwa, Dieudonné Boji Mungu; Eckardt, Winnie; Fruth, Barbara; Gillespie, Thomas R.; Gray, Maryke; Hohmann, Gottfried; Karhemere, Stomy; Kujirakwinja, Deo; Langergraber, Kevin; Muyembe, Jean Jacques; Nishuli, Radar; Pauly, Maude; Petrzelkova, Klara J.; Robbins, Martha M.; Todd, Angelique; Schubert, Grit; Stoinski, Tara S.; Wittig, Roman M.; Zuberbühler, Klaus; Peeters, Martine; Leendertz, Fabian H.; Calvignac-Spencer, Sébastien (2016-10) - Journal article
      It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of ...
    • Assessment of health in human faces is context-dependent 

      Morgan, Kate V.; Morton, Andrew; Whitehead, Ross D.; Perrett, David I.; Hurly, T. Andrew; Healy, Susan D. (2016-04) - Journal article
      When making decisions between options, humans are expected to choose the option that returns the highest benefit. In practice, however, adding inferior alternatives to the choice set can alter these decisions. Here we ...
    • Asymmetric paternal effect on offspring size linked to parent-of-origin expression of an insulin-like growth factor 

      Saldivar Lemus, Yolitzi; Vielle-Calzada, Jean-Philippe; Ritchie, Michael G.; Macías Garcia, Constantino (2017-06) - Journal article
      Sexual reproduction brings together reproductive partners whose long-term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their ...
    • Autobiographical memory specificity in response to verbal and pictorial cues in clinical depression 

      Ridout, Nathan; Dritschel, Barbara; Matthews, Keith; O'Carroll, Ronan (2016-06-01) - Journal article
      Background Depressed individuals have been consistently shown to exhibit problems in accessing specific memories of events from their past and instead tend to retrieve categorical summaries of events. The majority of studies ...
    • Automated face detection for occurrence and occupancy estimation in chimpanzees 

      Crunchant, Anne-Sophie; Egerer, Monika; Loos, Alexander; Burghardt, Tilo; Zuberbühler, Klaus; Corogenes, Katherine; Leinert, Vera; Kulik, Lars; Kühl, Hjalmar S. (2017-03) - Journal article
      Surveying endangered species is necessary to evaluate conservation effectiveness. Camera trapping and biometric computer vision are recent technological advances. They have impacted on the methods applicable to field surveys ...
    • Bayesian binning beats approximate alternatives: estimating peri-stimulus time histograms 

      Endres, D M; Oram, M W; Schindelin, J.E.; Foldiak, P (MIT Press, 2008) - Journal article
      The peristimulus time histogram (PSTH) and its more continuous cousin, the spike density function (SDF) are staples in the analytic toolkit of neurophysiologists. The former is usually obtained by binning spike trains, ...
    • Bayesian spatial NBDA for diffusion data with home-base coordinates 

      Nightingale, Glenna Faith; Laland, Kevin Neville; Hoppitt, William John Edward; Nightingale, Peter (2015-07-02) - Journal article
      Network-based diffusion analysis (NBDA) is a statistical method that allows the researcher to identify and quantify a social influence on the spread of behaviour through a population. Hitherto, NBDA analyses have not ...
    • BayesPiles : visualisation support for Bayesian network structure learning 

      Vogogias, Athanasios; Kennedy, Jessie; Archambault, Daniel; Bach, Benjamin; Smith, V Anne; Currant, Hannah (2018-11) - Journal article
      We address the problem of exploring, combining, and comparing large collections of scored, directed networks for understanding inferred Bayesian networks used in biology. In this field, heuristic algorithms explore the ...
    • Behavioral observation of xenopus tadpole swimming for neuroscience labs 

      Li, Wenchang; Wagner, Monica Anne; Porter, Nicola Jean (2014) - Journal article
      Neuroscience labs benefit from reliable, easily - monitored neural responses mediated by well - studied neural pathways . Xenopus laevis tadpoles have been used as a simple vertebrate model preparation in motor control ...
    • A behaviourally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles 

      Currie, Stephen Paul; Combes, Denis; Scott, Nicholas William; Simmers, John; Sillar, Keith Thomas (2016-03-18) - Journal article
      Locomotor control requires functional flexibility to support an animal’s full behavioural repertoire. This flexibility is partly endowed by neuromodulators, allowing neural networks to generate a range of motor output ...
    • Bifurcations of limit cycles in a reduced model of the Xenopus tadpole central pattern generator 

      Ferrario, Andrea; Merrison-Hort, Robert; Soffe, Stephen R.; Li, Wen-Chang; Borisyuk, Roman (2018-07-18) - Journal article
      We present the study of a minimal microcircuit controlling locomotion in two-day-old Xenopus tadpoles. During swimming, neurons in the spinal central pattern generator (CPG) generate anti-phase oscillations between left ...
    • Breeding limits foraging time : evidence of interrupted foraging response from body mass variation in a tropical environment 

      Nwaogu, Chima J.; Dietz, Maurine W.; Tieleman, B. Irene; Cresswell, Will (2017-04) - Journal article
      Birds should store body reserves if starvation risk is anticipated; this is known as an ‘interrupted foraging response’. If foraging remains unrestricted, however, body mass should remain low to limit the predation risk ...
    • The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons 

      Purohit, P; Perez-Branguli, F; Prots, I; Borger, Eva; Gunn-Moore, Frank J; Welzel, O; Loy, K; Wenzel, EM; Gromer, TW; Brachs, S; Holzer, M; Buslei, R; Fritsch, K; Regensburger, M; Bohm, KJ; Winner, B; Mielenz, D (2014-08-18) - Journal article
      Swiprosin-1/EFhd2 (EFhd2) is a cytoskeletal Ca2+ sensor protein strongly expressed in the brain. It has been shown to interact with mutant tau, which can promote neurodegeneration, but nothing is known about the physiological ...
    • The calcium-binding protein EFhd2 modulates synapse formation in vitro and Is linked to human dementia 

      Borger, Eva; Herrmann, Abigail; Mann, David; Spires-Jones, Tara; Gunn-Moore, Frank J (2014-10) - Journal article
      EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia. EFhd2 has cell type–specific ...
    • Can fear conditioning repel California sea lions from fishing activities? 

      Schakner, Zachary A.; Götz, Thomas; Janik, Vincent M.; Blumstein, Daniel T. (2017-10) - Journal article
      Marine mammal interactions with fisheries create conflicts that can threaten human safety, economic interests and marine mammal survival. A deterrent that capitalizes on learning mechanisms, like fear conditioning, may ...
    • A case-control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene 

      Hawi, Ziarih; Yates, Hannah; Pinar, Ari; Johnson, Beth; Tong, Janette; Pugsley, Kealan; Dark, Callum; Pauper, Mark; Klein, Marieke; Heussler, Helen S; Vance, Alasdair; Hiscock, Harriet; Fornito, Alex; Tiego, Jeggan; Finlay, Amy; Franke, Barbara; Gill, Michael; Kent, Lindsey Sian; Bellgrove, Mark A. (2018-12-18) - Journal article
      It is well-established that there is a strong genetic contribution to the aetiology of attention deficit hyperactivity disorder (ADHD). Here, we employed a hypothesis-free genome-wide association study (GWAS) design in a ...