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dc.contributor.authorParacchini, Silvia
dc.date.accessioned2021-09-27T11:30:10Z
dc.date.available2021-09-27T11:30:10Z
dc.date.issued2021-09-26
dc.identifier.citationParacchini , S 2021 , ' Recent advances in handedness genetics ' , Symmetry , vol. 13 , no. 10 , 1792 . https://doi.org/10.3390/sym13101792en
dc.identifier.issn2073-8994
dc.identifier.otherPURE: 275996210
dc.identifier.otherPURE UUID: 6ee0e01e-0efd-4fd2-8fd0-d34797d1de7d
dc.identifier.otherScopus: 85115913140
dc.identifier.urihttp://hdl.handle.net/10023/24028
dc.descriptionFunding: SP is supported by the Royal Society.en
dc.description.abstractAround the world, about 10% people prefer using their left-hand. What leads to this fixed proportion across populations and what determines left versus right preference at an individual level is far from being established. Genetic studies are a tool to answer these questions. Analysis in twins and family show that about 25% of handedness variance is due to genetics. In spite of very large cohorts, only a small fraction of this genetic component can be pinpoint to specific genes. Some of the genetic associations identified so far provide evidence for shared biology contributing to both handedness and cerebral asymmetries. In addition, they demonstrate that handedness is a highly polygenic trait. Typically, handedness is measured as the preferred hand for writing. This is a very convenient measure, especially to reach large sample sizes, but quantitative measures might capture different handedness dimensions and be better suited for genetic analyses. This paper reviews the latest findings from molecular genetic studies as well as the implications of using different ways of assessing handedness.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofSymmetryen
dc.rightsCopyright: © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectQuantitative traiten
dc.subjectHandednessen
dc.subjectNeurodevelopmenten
dc.subjectGWASen
dc.subjectHeritabilityen
dc.subjectPolygenic scoresen
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titleRecent advances in handedness geneticsen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.St Andrews Bioinformatics Uniten
dc.identifier.doihttps://doi.org/10.3390/sym13101792
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.mdpi.com/2073-8994/13/10/1792en


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