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dc.contributor.authorSigfrid, Louise
dc.contributor.authorDrake, Thomas M
dc.contributor.authorPauley, Ellen
dc.contributor.authorJesudason, Edwin C
dc.contributor.authorOlliaro, Piero
dc.contributor.authorLim, Wei Shen
dc.contributor.authorGillesen, Annelies
dc.contributor.authorBerry, Colin
dc.contributor.authorLowe, David J
dc.contributor.authorMcPeake, Joanne
dc.contributor.authorLone, Nazir
dc.contributor.authorMunblit, Daniel
dc.contributor.authorCevik, Muge
dc.contributor.authorCasey, Anna
dc.contributor.authorBannister, Peter
dc.contributor.authorRussell, Clark D
dc.contributor.authorGoodwin, Lynsey
dc.contributor.authorHo, Antonia
dc.contributor.authorTurtle, Lance
dc.contributor.authorO'Hara, Margaret E
dc.contributor.authorHastie, Claire
dc.contributor.authorDonohue, Chloe
dc.contributor.authorSpencer, Rebecca G
dc.contributor.authorDonegan, Cara
dc.contributor.authorGummery, Alison
dc.contributor.authorHarrison, Janet
dc.contributor.authorHardwick, Hayley E
dc.contributor.authorHastie, Claire E
dc.contributor.authorCarson, Gail
dc.contributor.authorMerson, Laura
dc.contributor.authorBaillie, J Kenneth
dc.contributor.authorOpenshaw, Peter
dc.contributor.authorHarrison, Ewen M
dc.contributor.authorDocherty, Annemarie B
dc.contributor.authorSemple, Malcolm G
dc.contributor.authorScott, Janet T
dc.contributor.authorISARIC global follow-up working group
dc.contributor.authorISARIC4C investigators
dc.date.accessioned2021-09-10T11:30:15Z
dc.date.available2021-09-10T11:30:15Z
dc.date.issued2021-09
dc.identifier275695982
dc.identifiere06c42b0-d751-46ec-8a7d-4db64590cc98
dc.identifier85112627608
dc.identifier000704988300016
dc.identifier.citationSigfrid , L , Drake , T M , Pauley , E , Jesudason , E C , Olliaro , P , Lim , W S , Gillesen , A , Berry , C , Lowe , D J , McPeake , J , Lone , N , Munblit , D , Cevik , M , Casey , A , Bannister , P , Russell , C D , Goodwin , L , Ho , A , Turtle , L , O'Hara , M E , Hastie , C , Donohue , C , Spencer , R G , Donegan , C , Gummery , A , Harrison , J , Hardwick , H E , Hastie , C E , Carson , G , Merson , L , Baillie , J K , Openshaw , P , Harrison , E M , Docherty , A B , Semple , M G , Scott , J T , ISARIC global follow-up working group & ISARIC4C investigators 2021 , ' Long Covid in adults discharged from UK hospitals after Covid-19 : a prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol ' , The Lancet Regional Health - Europe , vol. 8 , 100186 . https://doi.org/10.1016/j.lanepe.2021.100186en
dc.identifier.issn2666-7762
dc.identifier.otherRIS: urn:E66DB718D1D310BBBACF9CAF750799EE
dc.identifier.otherORCID: /0000-0003-1133-3874/work/99466510
dc.identifier.urihttps://hdl.handle.net/10023/23939
dc.descriptionFunding: This work is supported by grants from: the National Institute for Health Research (NIHR) [award CO-CIN-01], the Medical Research Council [grant MC_PC_19059], the Imperial Biomedical Research Centre (NIHR Imperial BRC, grant P45058), the Health Protection Research Unit (HPRU) in Respiratory Infections at Imperial College London and NIHR HPRU in Emerging and Zoonotic Infections at University of Liverpool, both in partnership with Public Health England, [NIHR award 200907], Wellcome Trust and Department for International Development [215091/Z/18/Z], and the Bill and Melinda Gates Foundation [OPP1209135], and Liverpool Experimental Cancer Medicine Centre (Grant Reference: C18616/A25153), NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013], EU Platform for European Preparedness Against (Re-) emerging Epidemics 1 [FP7 project 602525] and NIHR Clinical Research Network for providing infrastructure support for this research. LT is a Wellcome Trust clinical career development fellow, supported by grant number 205228/Z/16/Z. This research was funded in part, by the Wellcome Trust. PJMO is supported by a NIHR Senior Investigator Award [award 201385].en
dc.description.abstractBackground : This study sought to establish the long-term effects of Covid-19 following hospitalisation. Methods : 327 hospitalised participants, with SARS-CoV-2 infection were recruited into a prospective multicentre cohort study at least 3 months post-discharge. The primary outcome was self-reported recovery at least ninety days after initial Covid-19 symptom onset. Secondary outcomes included new symptoms, disability (Washington group short scale), breathlessness (MRC Dyspnoea scale) and quality of life (EQ5D-5L). Findings : 55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the most common (83%), followed by breathlessness (54%). 47% reported an increase in MRC dyspnoea scale of at least one grade. New or worse disability was reported by 24% of participants. The EQ5D-5L summary index was significantly worse following acute illness (median difference 0.1 points on a scale of 0 to 1, IQR: -0.2 to 0.0). Females under the age of 50 years were five times less likely to report feeling recovered (adjusted OR 5.09, 95% CI 1.64 to 15.74), were more likely to have greater disability (adjusted OR 4.22, 95% CI 1.12 to 15.94), twice as likely to report worse fatigue (adjusted OR 2.06, 95% CI 0.81 to 3.31) and seven times more likely to become more breathless (adjusted OR 7.15, 95% CI 2.24 to 22.83) than men of the same age. Interpretation : Survivors of Covid-19 experienced long-term symptoms, new disability, increased breathlessness, and reduced quality of life. These findings were present in young, previously healthy working age adults, and were most common in younger females.
dc.format.extent13
dc.format.extent1578651
dc.language.isoeng
dc.relation.ispartofThe Lancet Regional Health - Europeen
dc.subjectCovid-19en
dc.subjectLong-Coviden
dc.subjectLong-term outcomesen
dc.subjectPost-Coviden
dc.subjectPost-acute Covid-19en
dc.subjectQuality of lifeen
dc.subjectSequelaeen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subject3rd-DASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRA0421en
dc.titleLong Covid in adults discharged from UK hospitals after Covid-19 : a prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocolen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.identifier.doi10.1016/j.lanepe.2021.100186
dc.description.statusPeer revieweden


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