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Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia
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dc.contributor.author | GLIMP investigators | |
dc.contributor.author | Villafuerte, David | |
dc.contributor.author | Aliberti, Stefano | |
dc.contributor.author | Soni, Nilam J | |
dc.contributor.author | Faverio, Paola | |
dc.contributor.author | Marcos, Pedro J | |
dc.contributor.author | Wunderink, Richard G | |
dc.contributor.author | Rodriguez, Alejandro | |
dc.contributor.author | Sibila, Oriol | |
dc.contributor.author | Sanz, Francisco | |
dc.contributor.author | Martin-Loeches, Ignacio | |
dc.contributor.author | Menzella, Francesco | |
dc.contributor.author | Reyes, Luis F | |
dc.contributor.author | Jankovic, Mateja | |
dc.contributor.author | Spielmanns, Marc | |
dc.contributor.author | Restrepo, Marcos I | |
dc.date.accessioned | 2021-08-19T09:30:01Z | |
dc.date.available | 2021-08-19T09:30:01Z | |
dc.date.issued | 2020-05 | |
dc.identifier | 267634805 | |
dc.identifier | 1afbc4a9-6680-4924-a8da-b999d4dd25e9 | |
dc.identifier | 31385399 | |
dc.identifier | 85070513507 | |
dc.identifier.citation | GLIMP investigators , Villafuerte , D , Aliberti , S , Soni , N J , Faverio , P , Marcos , P J , Wunderink , R G , Rodriguez , A , Sibila , O , Sanz , F , Martin-Loeches , I , Menzella , F , Reyes , L F , Jankovic , M , Spielmanns , M & Restrepo , M I 2020 , ' Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia ' , Respirology , vol. 25 , no. 5 , pp. 543-551 . https://doi.org/10.1111/resp.13663 | en |
dc.identifier.issn | 1323-7799 | |
dc.identifier.uri | https://hdl.handle.net/10023/23797 | |
dc.description | N.J.S. is partially funded by the Department of Veterans Affairs, Quality Enhancement Research Initiative (QUERI) Partnered Evaluation Initiative Grant (HX002263-01A1). | en |
dc.description.abstract | Background and objective : Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. Methods : We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when ≥3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. Results : Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. Conclusion : This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP. | |
dc.format.extent | 9 | |
dc.format.extent | 1468249 | |
dc.language.iso | eng | |
dc.relation.ispartof | Respirology | en |
dc.subject | Community-acquired pneumonia | en |
dc.subject | Enterobacteriaceae | en |
dc.subject | Multidrug-resistance | en |
dc.subject | Prevalence | en |
dc.subject | Risk factors | en |
dc.subject | QR Microbiology | en |
dc.subject | E-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QR | en |
dc.title | Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Infection Group | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.identifier.doi | 10.1111/resp.13663 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-08-05 | |
dc.identifier.url | https://portal.findresearcher.sdu.dk/en/publications/prevalence-and-risk-factors-for-ienterobacteriaceaei-in-patients- | en |
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