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dc.contributor.authorChaplin, Marty
dc.contributor.authorKirkham, Jamie J.
dc.contributor.authorDwan, Kerry
dc.contributor.authorSloan, Derek J.
dc.contributor.authorDavies, Geraint
dc.contributor.authorJorgensen, Andrea L.
dc.date.accessioned2020-09-23T09:30:03Z
dc.date.available2020-09-23T09:30:03Z
dc.date.issued2020-09-21
dc.identifier270305907
dc.identifierb741bfd5-d145-4515-a472-c180eba215c7
dc.identifier85091439423
dc.identifier000574451200006
dc.identifier.citationChaplin , M , Kirkham , J J , Dwan , K , Sloan , D J , Davies , G & Jorgensen , A L 2020 , ' STrengthening the Reporting Of Pharmacogenetic Studies : development of the STROPS guideline ' , PLoS Medicine , vol. 17 , no. 9 , e1003344 . https://doi.org/10.1371/journal.pmed.1003344en
dc.identifier.issn1549-1277
dc.identifier.otherRIS: urn:9FCCB8E1B4EE2C23F40EFE348A32D304
dc.identifier.otherORCID: /0000-0002-7888-5449/work/80995342
dc.identifier.urihttps://hdl.handle.net/10023/20672
dc.descriptionMC is supported partly by Liverpool Reviews and Implementation Group (LRiG, based at the University of Liverpool), based on funding from the National Institute for Health Research Health Technology Assessment Programme (http://www.nets.nihr.ac.uk/programmes/hta), and partly by the Research, Evidence and Development Initiative (READ-It) project. READ-It (project number 300342-104) is funded by UK aid from the UK government.en
dc.description.abstractBackground Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size and, consequently, power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging because of poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies that has been developed using a widely accepted robust methodology. The objective of this project was to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline. Methods and findings We established a preliminary checklist of reporting items to be considered for inclusion in the guideline. We invited representatives of key stakeholder groups to participate in a 2-round Delphi survey. A total of 52 individuals participated in both rounds of the survey, scoring items with regards to their importance for inclusion in the STROPS guideline. We then held a consensus meeting, at which 8 individuals considered the results of the Delphi survey and voted on whether each item ought to be included in the final guideline. The STROPS guideline consists of 54 items and is accompanied by an explanation and elaboration document. The guideline contains items that are particularly important in the field of pharmacogenetics, such as the drug regimen of interest and whether adherence to treatment was accounted for in the conducted analyses. The guideline also requires that outcomes be clearly defined and justified, because in pharmacogenetic studies, there may be a greater number of possible outcomes than in other types of study (for example, disease–gene association studies). A limitation of this project is that our consensus meeting involved a small number of individuals, the majority of whom are based in the United Kingdom. Conclusions Our aim is for the STROPS guideline to improve the transparency of reporting of pharmacogenetic studies and also to facilitate the conduct of high-quality systematic reviews and meta-analyses. We encourage authors to adhere to the STROPS guideline when publishing pharmacogenetic studies.
dc.format.extent11
dc.format.extent293180
dc.language.isoeng
dc.relation.ispartofPLoS Medicineen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectDASen
dc.subject.lccRMen
dc.titleSTrengthening the Reporting Of Pharmacogenetic Studies : development of the STROPS guidelineen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.identifier.doi10.1371/journal.pmed.1003344
dc.description.statusPeer revieweden


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